Topics
DrosophilaInsect
embryogenesisAnatomical structure
cell cycleTelevision show
zygoticAnatomical structure
kinaseProtein
Cdk1Biomolecule
embryoAnatomical structure
At the mid-blastula transition (MBT), externally developing embryos refocus from increasing cell number to elaboration of the body plan. Studies in Drosophila reveal a sequence of changes in regulators of Cyclin:Cdk1 that increasingly restricts the activity of this cell cycle kinase to slow cell cycles during early embryogenesis. By reviewing these events, we provide an outline of the mechanisms slowing the cell cycle at and around the time of MBT. The perspectives developed should provide a guiding paradigm for the study of other MBT changes as the embryo transits from maternal control to a regulatory program centered on the expression of zygotic genes
lated. In most contexts, mitotic entry is controlled by complex inputs that govern the phosphorylati...
We examined the contribution of S phase in timing cell cycle progression during Drosophila embryogen...
The duration of S phase in early embryos is often short, and then increases as development proceeds ...
At the mid-blastula transition (MBT), externally developing embryos refocus from increasing cell num...
Rapid and synchronous syncytial mitotic cycles without gap phases characterize the initial phase of ...
Rapid and synchronous syncytial mitotic cycles without gap phases characterize the initial phase of ...
Many, if not most, embryos begin development with extremely short cell cycles that exhibit unusually...
Cell proliferation in early embryos by rapid cell cycles and its abrupt pause after a stereotypic nu...
Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucle...
In Drosophila embryos, the mid-blastula transition (MBT) dramatically remodels the cell cycle during...
During early development in many species, maternally supplied gene products permit the cell cycle to...
One of the most prominent features at the mid-blastula transition (MBT) observed in most embryos is ...
In preparation for the dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles sl...
Embryogenesis is typically initiated by a series of rapid mitotic divisions that are under maternal ...
Precise timing coordinates cell proliferation with embryonic morphogenesis. As Drosophila melanogast...
lated. In most contexts, mitotic entry is controlled by complex inputs that govern the phosphorylati...
We examined the contribution of S phase in timing cell cycle progression during Drosophila embryogen...
The duration of S phase in early embryos is often short, and then increases as development proceeds ...
At the mid-blastula transition (MBT), externally developing embryos refocus from increasing cell num...
Rapid and synchronous syncytial mitotic cycles without gap phases characterize the initial phase of ...
Rapid and synchronous syncytial mitotic cycles without gap phases characterize the initial phase of ...
Many, if not most, embryos begin development with extremely short cell cycles that exhibit unusually...
Cell proliferation in early embryos by rapid cell cycles and its abrupt pause after a stereotypic nu...
Externally deposited eggs begin development with an immense cytoplasm and a single overwhelmed nucle...
In Drosophila embryos, the mid-blastula transition (MBT) dramatically remodels the cell cycle during...
During early development in many species, maternally supplied gene products permit the cell cycle to...
One of the most prominent features at the mid-blastula transition (MBT) observed in most embryos is ...
In preparation for the dramatic morphogenetic events of gastrulation, rapid embryonic cell cycles sl...
Embryogenesis is typically initiated by a series of rapid mitotic divisions that are under maternal ...
Precise timing coordinates cell proliferation with embryonic morphogenesis. As Drosophila melanogast...
lated. In most contexts, mitotic entry is controlled by complex inputs that govern the phosphorylati...
We examined the contribution of S phase in timing cell cycle progression during Drosophila embryogen...
The duration of S phase in early embryos is often short, and then increases as development proceeds ...
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