Ependyma have been proposed as adult neural stem cells that provide the majority of newly proliferated scar-forming astrocytes that protect tissue and function after spinal cord injury (SCI). This proposal was based on small, midline stab SCI. Here, we tested the generality of this proposal by using a genetic knock-in cell fate mapping strategy in different murine SCI models. After large crush injuries across the entire spinal cord, ependyma-derived progeny remained local, did not migrate and contributed few cells of any kind and less than 2%, if any, of the total newly proliferated and molecularly confirmed scar-forming astrocytes. Stab injuries that were near to but did not directly damage ependyma, contained no ependyma-derived cells. Ou...
Injury to the central nervous system (CNS) is one of man's most handicapping situations resulting in...
Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely re...
SummarySeveral distinct cell types in the adult central nervous system have been suggested to act as...
Ependyma have been proposed as adult neural stem cells that provide the majority of newly proliferat...
Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have ...
Spinal cord ependymal cells display neural stem cell properties in vitro and generate scar-forming a...
AbstractStem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). ...
AbstractStem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). ...
Abstract Ependymal cells with stem cell properties reside in the adult spinal cord around the centra...
Injury to the central nervous system (CNS) is one of man's most handicapping situations resulting in...
The neural stem cell capacity of the spinal cord is contained within the ependymal cell population. ...
AbstractNew neurons are continuously added in specific regions of the adult mammalian central nervou...
SummarySeveral distinct cell types in the adult central nervous system have been suggested to act as...
Ependymal cells reside in the adult spinal cord and display stem cell properties in vitro. They prol...
The adult mammalian spinal cord has limited regenerative capacity in settings such as spinal cord in...
Injury to the central nervous system (CNS) is one of man's most handicapping situations resulting in...
Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely re...
SummarySeveral distinct cell types in the adult central nervous system have been suggested to act as...
Ependyma have been proposed as adult neural stem cells that provide the majority of newly proliferat...
Stem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). We have ...
Spinal cord ependymal cells display neural stem cell properties in vitro and generate scar-forming a...
AbstractStem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). ...
AbstractStem cells have a high therapeutic potential for the treatment of spinal cord injury (SCI). ...
Abstract Ependymal cells with stem cell properties reside in the adult spinal cord around the centra...
Injury to the central nervous system (CNS) is one of man's most handicapping situations resulting in...
The neural stem cell capacity of the spinal cord is contained within the ependymal cell population. ...
AbstractNew neurons are continuously added in specific regions of the adult mammalian central nervou...
SummarySeveral distinct cell types in the adult central nervous system have been suggested to act as...
Ependymal cells reside in the adult spinal cord and display stem cell properties in vitro. They prol...
The adult mammalian spinal cord has limited regenerative capacity in settings such as spinal cord in...
Injury to the central nervous system (CNS) is one of man's most handicapping situations resulting in...
Transected axons fail to regrow in the mature central nervous system. Astrocytic scars are widely re...
SummarySeveral distinct cell types in the adult central nervous system have been suggested to act as...