Add to ORKGIncreasing the thermogenic activity of adipocytes holds promise as an approach to combating human obesity and related metabolic diseases. We identified induction of mouse PR domain containing 4 (Prdm4) by the small molecule butein as a means to induce expression of uncoupling protein 1 (Ucp1), increase energy expenditure, and stimulate the generation of thermogenic adipocytes. This study highlights a Prdm4-dependent pathway, modulated by small molecules, that stimulates browning of white adipose tissue
(1) Background: Brown adipose tissue (BAT) burns energy to produce heat. Cyanidin-3-O-glucoside (C3G...
p38 has long been known as a central mediator of protein kinase A (PKA) signaling in brown adipocyte...
The prevalence of obesity and type 2 diabetes has become a major economic and medical burden worldwi...
Abstract Stimulation of white adipose tissue (WAT) browning is considered as a potential approach to...
Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adi...
Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tis...
The alarming rise in the incidence of obesity found throughout the world has precipitated a need to ...
Summary: Transcriptional co-activator Prdm16 controls brown fat development and white fat browning, ...
Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- a...
Obesity and its associated complications, including Type 2 diabetes, are increasing at an epidemic r...
The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-ind...
White adipocytes contribute to energy storage, accumulating lipid droplets, whereas brown and beige ...
BACKGROUND: The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold...
Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white...
Brown/beige adipocytes, which are derived from skeletal muscle/smooth muscle-lineage cells, consume ...
(1) Background: Brown adipose tissue (BAT) burns energy to produce heat. Cyanidin-3-O-glucoside (C3G...
p38 has long been known as a central mediator of protein kinase A (PKA) signaling in brown adipocyte...
The prevalence of obesity and type 2 diabetes has become a major economic and medical burden worldwi...
Abstract Stimulation of white adipose tissue (WAT) browning is considered as a potential approach to...
Chronic adrenergic activation leads to the emergence of beige adipocytes in some depots of white adi...
Understanding mechanisms by which a population of beige adipocytes is increased in white adipose tis...
The alarming rise in the incidence of obesity found throughout the world has precipitated a need to ...
Summary: Transcriptional co-activator Prdm16 controls brown fat development and white fat browning, ...
Background The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- a...
Obesity and its associated complications, including Type 2 diabetes, are increasing at an epidemic r...
The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold- and diet-ind...
White adipocytes contribute to energy storage, accumulating lipid droplets, whereas brown and beige ...
BACKGROUND: The uncoupling protein 1 (UCP1) is a hallmark of brown adipocytes and pivotal for cold...
Brown adipocytes are specialised in dissipating energy through adaptive thermogenesis, whereas white...
Brown/beige adipocytes, which are derived from skeletal muscle/smooth muscle-lineage cells, consume ...
(1) Background: Brown adipose tissue (BAT) burns energy to produce heat. Cyanidin-3-O-glucoside (C3G...
p38 has long been known as a central mediator of protein kinase A (PKA) signaling in brown adipocyte...
The prevalence of obesity and type 2 diabetes has become a major economic and medical burden worldwi...