Add to ORKGGenetically modified mice carrying engrafted human tissues provide useful models to study human cell biology in physiologically relevant contexts. However, there remain several obstacles limiting the compatibility of human cells within their mouse hosts. Among these is inadequate cross-reactvitiy between certain mouse cytokines and human cellular receptors, depriving the graft of important survival and growth signals. To circumvent this problem, we utilized a lentivirus-based delivery system to express physiologically relevant levels of human interleukin-7 (hIL-7) in Rag2-/-gammac-/- mice following a single intravenous injection. hIL-7 promoted homeostatic proliferation of both adoptively transferred and endogenously generated T-cells in Ra...
<p>Immunodeficient mice reconstituted with human immune tissues and cells (humanized mice) are relev...
Humanized mouse models have become increasingly valuable tools to study human hematopoiesis and infe...
Human immunodeficiency virus (HIV) has infected millions of people worldwide and continues to be a m...
Genetically modified mice carrying engrafted human tissues provide useful models to study human cell...
Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the h...
Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the h...
HIV vaccine preclinical testing is difficult because HIV’s only relevant hosts are humans and no cor...
Abstract Substantial improvements have been made in recent years in the ability to engraft human cel...
Because of the limited tropism of HIV, in vivo modeling of this virus has been almost exclusively li...
International audienceLentiviral vectors have been tested as vaccination vectors in anti-tumoral and...
International audienceTargeting viral entry is the most likely gene therapy strategy to succeed in p...
International audiencePlaying a central role in both innate and adaptive immunity, CD4(+) T cells ar...
Playing a central role in both innate and adaptive immunity, CD4+ T cells are a key target for genet...
BACKGROUND: Mice harboring a human immune system (a.k.a. “humanized” mice) are a revolutionary small...
In recent years, the technology of constructing chimeric mice with humanized immune systems has mark...
<p>Immunodeficient mice reconstituted with human immune tissues and cells (humanized mice) are relev...
Humanized mouse models have become increasingly valuable tools to study human hematopoiesis and infe...
Human immunodeficiency virus (HIV) has infected millions of people worldwide and continues to be a m...
Genetically modified mice carrying engrafted human tissues provide useful models to study human cell...
Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the h...
Humanized mouse models generated with human hematopoietic stem cells (HSCs) and reconstituting the h...
HIV vaccine preclinical testing is difficult because HIV’s only relevant hosts are humans and no cor...
Abstract Substantial improvements have been made in recent years in the ability to engraft human cel...
Because of the limited tropism of HIV, in vivo modeling of this virus has been almost exclusively li...
International audienceLentiviral vectors have been tested as vaccination vectors in anti-tumoral and...
International audienceTargeting viral entry is the most likely gene therapy strategy to succeed in p...
International audiencePlaying a central role in both innate and adaptive immunity, CD4(+) T cells ar...
Playing a central role in both innate and adaptive immunity, CD4+ T cells are a key target for genet...
BACKGROUND: Mice harboring a human immune system (a.k.a. “humanized” mice) are a revolutionary small...
In recent years, the technology of constructing chimeric mice with humanized immune systems has mark...
<p>Immunodeficient mice reconstituted with human immune tissues and cells (humanized mice) are relev...
Humanized mouse models have become increasingly valuable tools to study human hematopoiesis and infe...
Human immunodeficiency virus (HIV) has infected millions of people worldwide and continues to be a m...