Host cytokine responses to Brucella abortus infection are elicited predominantly by the deployment of a type IV secretion system (T4SS). However, the mechanism by which the T4SS elicits inflammation remains unknown. Here we show that translocation of the T4SS substrate VceC into host cells induces proinflammatory responses. Ectopically expressed VceC interacted with the endoplasmic reticulum (ER) chaperone BiP/Grp78 and localized to the ER of HeLa cells. ER localization of VceC required a transmembrane domain in its N terminus. Notably, the expression of VceC resulted in reorganization of ER structures. In macrophages, VceC was required for B. abortus-induced inflammation by induction of the unfolded protein response by a process requiring ...
Brucellae are intracellular facultative pathogenic bacteria which are able to invade professional an...
Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host ...
Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. B...
Host cytokine responses to Brucella abortus infection are elicited predominantly by the deployment o...
Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bact...
Brucella melitensis is a facultative intracellular bacterium that causes brucellosis, the most preva...
Perturbation of the endoplasmic reticulum (ER), a central organelle of the cell, can have critical c...
ABSTRACT Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracell...
<div><p><i>Brucella</i> species replicate within host cells in the form of endoplasmic reticulum (ER...
Brucella species replicate within host cells in the form of endoplasmic reticulum (ER)-derived vacuo...
<div><p><i>Brucella melitensis</i> is a facultative intracellular bacterium that causes brucellosis,...
The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from ...
Brucella abortus infects the placenta of pregnant cows, where it replicates to high levels and trigg...
<div><p>The intracellular pathogenic bacterium <i>Brucella</i> generates a replicative vacuole (rBCV...
Pathogens are detected by innate immune receptors that, upon activation, orchestrate an appropriate ...
Brucellae are intracellular facultative pathogenic bacteria which are able to invade professional an...
Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host ...
Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. B...
Host cytokine responses to Brucella abortus infection are elicited predominantly by the deployment o...
Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracellular bact...
Brucella melitensis is a facultative intracellular bacterium that causes brucellosis, the most preva...
Perturbation of the endoplasmic reticulum (ER), a central organelle of the cell, can have critical c...
ABSTRACT Subversion of endoplasmic reticulum (ER) function is a feature shared by multiple intracell...
<div><p><i>Brucella</i> species replicate within host cells in the form of endoplasmic reticulum (ER...
Brucella species replicate within host cells in the form of endoplasmic reticulum (ER)-derived vacuo...
<div><p><i>Brucella melitensis</i> is a facultative intracellular bacterium that causes brucellosis,...
The intracellular pathogenic bacterium Brucella generates a replicative vacuole (rBCV) derived from ...
Brucella abortus infects the placenta of pregnant cows, where it replicates to high levels and trigg...
<div><p>The intracellular pathogenic bacterium <i>Brucella</i> generates a replicative vacuole (rBCV...
Pathogens are detected by innate immune receptors that, upon activation, orchestrate an appropriate ...
Brucellae are intracellular facultative pathogenic bacteria which are able to invade professional an...
Brucella abortus, the bacterial agent of the worldwide zoonosis brucellosis, primarily infects host ...
Bacterial infection induces inflammasome activation and release of interleukin-1 (IL-1) cytokines. B...