A series of novel amphiphilic macromolecules composed of alkyl chains as the hydrophobic block and poly(ethylene glycol) as the hydrophilic block were designed to inhibit highly oxidized low density lipoprotein (hoxLDL) uptake by synthesizing macromolecules with negatively charged moieties (ie, carboxylic acids) located in the two different blocks. The macromolecules have molecular weights around 5,500 g/mol, form micelles in aqueous solution with an average size of 20-35 nm, and display critical micelle concentration values as low as 10(-7) M. Their charge densities and hydrodynamic size in physiological buffer solutions correlated with the hydrophobic/ hydrophilic block location and quantity of the carboxylate groups. Generally, carboxyla...
Atherosclerosis, an inflammatory lipid-rich plaque disease is perpetuated by the unregulated scaveng...
Atherosclerosis, an inflammatory lipid-rich plaque disease is perpetuated by the unregulated scaveng...
Liposomes are potential drug carriers for atherosclerosis therapy due to low immunogenicity and ease...
A series of novel amphiphilic macromolecules composed of alkyl chains as the hydrophobic block and p...
Polymeric micelles are spherical assemblies of amphiphilic polymers widely studied for many biomedic...
Amphiphilic macromolecules (AMs) composed of sugar backbones modified with branched aliphatic chains...
Amphiphilic macromolecules (AMs) composed of sugar backbones modified with branched aliphatic chains...
The hypothesis of this research is that atherosclerosis, the principal pathology underlying vascular...
Amphiphilic molecules are comprised of hydrophobic and hydrophilic domains. These molecules possess ...
A major cause of cardiovascular disease is atherosclerosis, the progressive accumulation and modific...
Novel amphiphilic star-like macromolecules (ASM) and amphiphilic scorpion-like macromolecules (AScM)...
Scavenger receptors mediate the uptake of oxidized low density lipoprotein (oxLDL), leading to chole...
Amphiphilic molecules, comprised of both hydrophilic and hydrophobic domains, have been extensively ...
Amphiphilic molecules comprised of a hydrophilic and hydrophobic domain are able to self-assemble in...
Cancer is the second most common death in the US accounting for 25% of all deaths. Many of the pote...
Atherosclerosis, an inflammatory lipid-rich plaque disease is perpetuated by the unregulated scaveng...
Atherosclerosis, an inflammatory lipid-rich plaque disease is perpetuated by the unregulated scaveng...
Liposomes are potential drug carriers for atherosclerosis therapy due to low immunogenicity and ease...
A series of novel amphiphilic macromolecules composed of alkyl chains as the hydrophobic block and p...
Polymeric micelles are spherical assemblies of amphiphilic polymers widely studied for many biomedic...
Amphiphilic macromolecules (AMs) composed of sugar backbones modified with branched aliphatic chains...
Amphiphilic macromolecules (AMs) composed of sugar backbones modified with branched aliphatic chains...
The hypothesis of this research is that atherosclerosis, the principal pathology underlying vascular...
Amphiphilic molecules are comprised of hydrophobic and hydrophilic domains. These molecules possess ...
A major cause of cardiovascular disease is atherosclerosis, the progressive accumulation and modific...
Novel amphiphilic star-like macromolecules (ASM) and amphiphilic scorpion-like macromolecules (AScM)...
Scavenger receptors mediate the uptake of oxidized low density lipoprotein (oxLDL), leading to chole...
Amphiphilic molecules, comprised of both hydrophilic and hydrophobic domains, have been extensively ...
Amphiphilic molecules comprised of a hydrophilic and hydrophobic domain are able to self-assemble in...
Cancer is the second most common death in the US accounting for 25% of all deaths. Many of the pote...
Atherosclerosis, an inflammatory lipid-rich plaque disease is perpetuated by the unregulated scaveng...
Atherosclerosis, an inflammatory lipid-rich plaque disease is perpetuated by the unregulated scaveng...
Liposomes are potential drug carriers for atherosclerosis therapy due to low immunogenicity and ease...