Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxidasins are extracellular peroxidases implicated in the unique sulfilimine cross-links between type IV basement membrane collagens. Loss of function in the Caenorhabditis elegans peroxidasin PXN-2 results in fully penetrant embryonic or larval lethality. Using genetic suppressor screening, we find that the requirement for PXN-2 in development can be bypassed by gain of function in multiple genes encoding other basement membrane components, or proteins implicated in cell-matrix attachment. We identify multiple alleles of let-805, encoding the transmembrane protein myotactin, which suppress phenotypes of pxn-2 null mutants and of other basement ...
Maintaining homeostasis is critical for all organisms. In this work, I describe a new cellular homeo...
Myogenesis in Caenorhabditis elegans is composed of several stages: the generation of presumptive m...
Few studies have investigated whether or not there is an interdependence between osmoregulation and ...
Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxi...
Peroxidasin is a member of the myeloperoxidase family of proteins but has novel domains and localiza...
Spon-1 and pxn-2 are essential basement membrane genes crucial to the elongation stage of C. elegans...
The organs of animal embryos are typically covered with an extracellular matrix (ECM) that must be c...
AbstractBasement membranes are thin sheets of specialized extracellular matrix molecules that are im...
2, are extracellular peroxidases; pxn-2 is involved in muscle-epidermal attachment during embryonic ...
This study is to address the role of extracellular matrix (ECM) in animal development. During develo...
The glp-1 gene functions in two inductive cellular interactions and in development of the embryonic ...
Type IV collagen forms a network that provides the major structural support of basement membranes. W...
International audienceHemidesmosomes connect the extracellular matrix (ECM) to intermediate filament...
SummaryHemidesmosomes connect the extracellular matrix (ECM) to intermediate filaments through ECM r...
Perlecan, a basement membrane protein, was found to be significantly decreased in collagen IV mutant...
Maintaining homeostasis is critical for all organisms. In this work, I describe a new cellular homeo...
Myogenesis in Caenorhabditis elegans is composed of several stages: the generation of presumptive m...
Few studies have investigated whether or not there is an interdependence between osmoregulation and ...
Basement membranes are extracellular matrices essential for embryonic development in animals. Peroxi...
Peroxidasin is a member of the myeloperoxidase family of proteins but has novel domains and localiza...
Spon-1 and pxn-2 are essential basement membrane genes crucial to the elongation stage of C. elegans...
The organs of animal embryos are typically covered with an extracellular matrix (ECM) that must be c...
AbstractBasement membranes are thin sheets of specialized extracellular matrix molecules that are im...
2, are extracellular peroxidases; pxn-2 is involved in muscle-epidermal attachment during embryonic ...
This study is to address the role of extracellular matrix (ECM) in animal development. During develo...
The glp-1 gene functions in two inductive cellular interactions and in development of the embryonic ...
Type IV collagen forms a network that provides the major structural support of basement membranes. W...
International audienceHemidesmosomes connect the extracellular matrix (ECM) to intermediate filament...
SummaryHemidesmosomes connect the extracellular matrix (ECM) to intermediate filaments through ECM r...
Perlecan, a basement membrane protein, was found to be significantly decreased in collagen IV mutant...
Maintaining homeostasis is critical for all organisms. In this work, I describe a new cellular homeo...
Myogenesis in Caenorhabditis elegans is composed of several stages: the generation of presumptive m...
Few studies have investigated whether or not there is an interdependence between osmoregulation and ...