The glypicans are a family of glycosylphosphatidylinositol (GPI)-anchored proteoglycans that, by virtue of their cell-surface localization and possession of heparan sulfate chains, may regulate the responses of cells to numerous heparin-binding growth factors, cell adhesion molecules, and extracellular matrix components. Mutations in one glypican cause a syndrome of human birth defects, suggesting important roles for these proteoglycans in development. Glypican-1, the first-discovered member of this family, was originally found in cultured fibroblasts, and later shown to be a major proteoglycan of the mature and developing brain. Here we examine the pattern of glypican-1 mRNA and protein expression more widely in the developing rodent, conc...
Cellular interactions in neural development are influenced by various extracellular proteins, many o...
Glypicans are major cell surface heparan sulfate proteoglycans, the structures of which are characte...
Heparan sulfate proteoglycans are important extracellular matrix components. Their binding to a vari...
Cell-surface proteoglycans have been implicated in cell responses to growth factors, extracellular m...
Heparan sulfate is ubiquitous at the cell surface, where it is expressed predominantly on proteoglyc...
BackgroundCell surface heparan sulfate proteoglycans (HSPGs) act as co-receptors for multiple famili...
Heparan sulfate proteoglycans (HSPGs) are found on the surface of all adherent cells and participate...
AbstractGlypicans represent a family of six cell surface heparan sulfate proteoglycans in vertebrate...
Cerebroglycan is a glycosylphosphatidylinositol-linked integral membrane heparan sulfate proteoglyca...
AbstractCerebroglycan is a glycosylphosphatidylinositol-linked integral membrane heparan sulfate pro...
One of the most important events during central nervous system (CNS) development is the communicatio...
A family of lipid-linked heparan sulfate (HS) proteoglycans, later named glypicans, were identified ...
Glypicans are a family of cell-surface proteoglycans that regulate Wnt, hedgehog, bone morphogenetic...
Heparan sulfate Proteoglycans (HSPG) are ubiquitous molecules with indispensable functions in variou...
Glypicans are cell-surface heparan sulfate proteoglycans that regulate Wnt, Hedgehog, bone morphogen...
Cellular interactions in neural development are influenced by various extracellular proteins, many o...
Glypicans are major cell surface heparan sulfate proteoglycans, the structures of which are characte...
Heparan sulfate proteoglycans are important extracellular matrix components. Their binding to a vari...
Cell-surface proteoglycans have been implicated in cell responses to growth factors, extracellular m...
Heparan sulfate is ubiquitous at the cell surface, where it is expressed predominantly on proteoglyc...
BackgroundCell surface heparan sulfate proteoglycans (HSPGs) act as co-receptors for multiple famili...
Heparan sulfate proteoglycans (HSPGs) are found on the surface of all adherent cells and participate...
AbstractGlypicans represent a family of six cell surface heparan sulfate proteoglycans in vertebrate...
Cerebroglycan is a glycosylphosphatidylinositol-linked integral membrane heparan sulfate proteoglyca...
AbstractCerebroglycan is a glycosylphosphatidylinositol-linked integral membrane heparan sulfate pro...
One of the most important events during central nervous system (CNS) development is the communicatio...
A family of lipid-linked heparan sulfate (HS) proteoglycans, later named glypicans, were identified ...
Glypicans are a family of cell-surface proteoglycans that regulate Wnt, hedgehog, bone morphogenetic...
Heparan sulfate Proteoglycans (HSPG) are ubiquitous molecules with indispensable functions in variou...
Glypicans are cell-surface heparan sulfate proteoglycans that regulate Wnt, Hedgehog, bone morphogen...
Cellular interactions in neural development are influenced by various extracellular proteins, many o...
Glypicans are major cell surface heparan sulfate proteoglycans, the structures of which are characte...
Heparan sulfate proteoglycans are important extracellular matrix components. Their binding to a vari...