An atomistic understanding of metal transport in the human body is critical to anticipate the side effects of metal-based therapeutics and holds promise for new drugs and drug delivery designs. Human serum transferrin (hTF) is a central part of the transport processes because of its ubiquitous ferrying of physiological Fe(III) and other transition metals to tightly controlled parts of the body. There is an atomistic mechanism for the uptake process with Fe(III), but not for the release process, or for other metals. This study provides initial insight into these processes for a range of transition metals-Ti(IV), Co(III), Fe(III), Ga(III), Cr(III), Fe(II), Zn(II)-through fully atomistic, extensive quantum mechanical/discrete molecular dynamic...
Iron is important for human health and serves as a co-factor in a variety of proteins and enzymes. H...
A commentary is offered on the factors underlying the different binding affinity of human serum tran...
Human serum transferrin (hTF) is a single-chain bilobal glycoprotein (80 kDa) which transports Fe3+ ...
An atomistic understanding of metal transport in the human body is critical to anticipate the side e...
Serum transferrin (sTf) carries iron in blood serum and delivers it into cells by receptor-mediated ...
Serumtransferrin (sTf) transports iron in serum and internalizes in cells via receptor mediated endo...
Serum transferrin (sTf) carries iron in blood serum and delivers it into cells by receptor-mediated ...
Human serum Transferrin (hTf) is a ∼80 kDa protein, whose function is iron sequestration and transpo...
This journal suppl. entitled: 12th European Biological Inorganic Chemistry Conference, Zurich, Switz...
Transferrins constitute a class of metalloproteins that sequester and transport iron in vertebrates....
With the advances in three-dimensional structure determination techniques, high quality structures o...
Transferrins comprise a class of monomeric glycoproteins found in all vertebrates, whose function is...
Human serum transferrin (hTf) transports ferric ions in the blood stream and delivers them to cells ...
The dynamical and thermodynamic behavior of human transferrin (hTf) protein in saline aqueous soluti...
Human serum transferrin (hTF) binds Fe(III) tightly but reversibly, and delivers it to cells via a r...
Iron is important for human health and serves as a co-factor in a variety of proteins and enzymes. H...
A commentary is offered on the factors underlying the different binding affinity of human serum tran...
Human serum transferrin (hTF) is a single-chain bilobal glycoprotein (80 kDa) which transports Fe3+ ...
An atomistic understanding of metal transport in the human body is critical to anticipate the side e...
Serum transferrin (sTf) carries iron in blood serum and delivers it into cells by receptor-mediated ...
Serumtransferrin (sTf) transports iron in serum and internalizes in cells via receptor mediated endo...
Serum transferrin (sTf) carries iron in blood serum and delivers it into cells by receptor-mediated ...
Human serum Transferrin (hTf) is a ∼80 kDa protein, whose function is iron sequestration and transpo...
This journal suppl. entitled: 12th European Biological Inorganic Chemistry Conference, Zurich, Switz...
Transferrins constitute a class of metalloproteins that sequester and transport iron in vertebrates....
With the advances in three-dimensional structure determination techniques, high quality structures o...
Transferrins comprise a class of monomeric glycoproteins found in all vertebrates, whose function is...
Human serum transferrin (hTf) transports ferric ions in the blood stream and delivers them to cells ...
The dynamical and thermodynamic behavior of human transferrin (hTf) protein in saline aqueous soluti...
Human serum transferrin (hTF) binds Fe(III) tightly but reversibly, and delivers it to cells via a r...
Iron is important for human health and serves as a co-factor in a variety of proteins and enzymes. H...
A commentary is offered on the factors underlying the different binding affinity of human serum tran...
Human serum transferrin (hTF) is a single-chain bilobal glycoprotein (80 kDa) which transports Fe3+ ...