Engineering the Mesoporous Silica Nanoparticles to Chelate to Metal Ions for Bioapplications

This dissertation focuses on improving cancer therapies and imaging by utilizing non-harmful material such as metal ions to replace traditional cancer therapies. The three chapters of this dissertation are presented as follows: 1. In Vitro Delivery of Calcium Ions by Nanogated Mesoporous Silica Nanoparticles to Induce Cancer Cellular Apoptosis. 2. Enhanced Fenton Reaction for Reactive Oxygen Species Generation by Iron Ion-Loaded Mesoporous Silica Nanoparticles for Cancer Therapy. 3. Cellular uptake efficiency study of enhanced T1 relaxivity gadolinium loaded iminodiacetic acid modified mesoporous silica nanoparticle