The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend against environmental insults. While studies have shown that smoking alters bronchial epithelial function and morphology, its precise effects on specific cell types and overall tissue composition are unclear. We used single-cell RNA sequencing to profile bronchial epithelial cells from six never and six current smokers. Unsupervised analyses led to the characterization of a set of toxin metabolism genes that localized to smoker ciliated cells, tissue remodeling associated with a loss of club cells and extensive goblet cell hyperplasia, and a previously unidentified peri-goblet epithelial subpopulation in smokers who expressed a marker of bron...
Abstract Background Aging is affected by genetic and environmental factors, and cigarette smoking is...
Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the ...
Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the ...
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend ...
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend ...
The differentiated human airway epithelium consists of different cell types forming a polarized and ...
The differentiated human airway epithelium consists of different cell types forming a polarized and ...
Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and causes remodelin...
BACKGROUND: Cigarette smoking is a leading cause of preventable death and a significant cause of lun...
The human bronchial epithelium is composed of multiple, discrete cell types that cooperate to perfor...
BACKGROUND: Despite the well-known detrimental effects of cigarette smoke (CS), little is known abou...
BACKGROUND: Despite the well-known detrimental effects of cigarette smoke (CS), little is known abou...
Cigarette smoking is the main risk factor for the development of squamous cell lung carcinoma (SCC)....
Abstract Background Lung cancer is the most common cause of cancer-related deaths. Tobacco smoke exp...
Abstract Background Cigarette smoke (CS) exposure causes an abnormal inflammatory response, which ca...
Abstract Background Aging is affected by genetic and environmental factors, and cigarette smoking is...
Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the ...
Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the ...
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend ...
The human bronchial epithelium is composed of multiple distinct cell types that cooperate to defend ...
The differentiated human airway epithelium consists of different cell types forming a polarized and ...
The differentiated human airway epithelium consists of different cell types forming a polarized and ...
Smoking is a major risk factor for chronic obstructive pulmonary disease (COPD) and causes remodelin...
BACKGROUND: Cigarette smoking is a leading cause of preventable death and a significant cause of lun...
The human bronchial epithelium is composed of multiple, discrete cell types that cooperate to perfor...
BACKGROUND: Despite the well-known detrimental effects of cigarette smoke (CS), little is known abou...
BACKGROUND: Despite the well-known detrimental effects of cigarette smoke (CS), little is known abou...
Cigarette smoking is the main risk factor for the development of squamous cell lung carcinoma (SCC)....
Abstract Background Lung cancer is the most common cause of cancer-related deaths. Tobacco smoke exp...
Abstract Background Cigarette smoke (CS) exposure causes an abnormal inflammatory response, which ca...
Abstract Background Aging is affected by genetic and environmental factors, and cigarette smoking is...
Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the ...
Although prior studies have demonstrated a smoking-induced field of molecular injury throughout the ...
Add to ORKG