Add to ORKGThe MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, cooperates with B-Myb to activate genes required for the G2 and M phases of the cell cycle. We have identified the domain in B-Myb that is essential for the assembly of the Myb-MuvB (MMB) complex. We determined a crystal structure that reveals how this B-Myb domain binds MuvB through the adaptor protein LIN52 and the scaffold protein LIN9. The structure and biochemical analysis provide an understanding of how oncogenic B-Myb is recruited to regulate genes required for cell-cycle progression, and the MMB interface presents a potential therapeutic target to inhibit cancer cell proliferation
The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins wit...
The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins wit...
High expression of B-Myb (encoded by MYBL2), an oncogenic transcription factor, is associated with c...
The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, co...
The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, co...
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and ser...
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and ser...
The B-Myb oncogene is overexpressed and increasingly considered a biomarker for several human cancer...
The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncer...
The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncer...
The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncer...
Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of p...
Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of p...
Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of p...
Cancer cells are characterized by uncontrolled proliferation, whereas the ability to enter quiescenc...
The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins wit...
The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins wit...
High expression of B-Myb (encoded by MYBL2), an oncogenic transcription factor, is associated with c...
The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, co...
The MuvB transcriptional regulatory complex, which controls cell-cycle-dependent gene expression, co...
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and ser...
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and ser...
The B-Myb oncogene is overexpressed and increasingly considered a biomarker for several human cancer...
The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncer...
The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncer...
The chromatin architecture in promoters is thought to regulate gene expression, but it remains uncer...
Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of p...
Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of p...
Genes encoding the core cell cycle machinery are transcriptionally regulated by the MuvB family of p...
Cancer cells are characterized by uncontrolled proliferation, whereas the ability to enter quiescenc...
The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins wit...
The DREAM complex represses cell cycle genes during quiescence through scaffolding MuvB proteins wit...
High expression of B-Myb (encoded by MYBL2), an oncogenic transcription factor, is associated with c...