Constitutive activation of the non-receptor tyrosine kinase c-Abl (cellular Abelson tyrosine protein kinase 1, Abl1) in the Bcr (breakpoint cluster region)-Abl1 fusion oncoprotein is the molecular cause of chronic myeloid leukaemia (CML). Recent studies have indicated that an interaction between the SH2 (Src-homology 2) domain and the N-lobe (N-terminal lobe) of the c-Abl kinase domain (KD) has a critical role in leukaemogenesis [Grebien et al. (2011) Cell 147, 306-319; Sherbenou et al. (2010) Blood 116, 3278-3285]. To dissect the structural basis of this phenomenon, we studied c-Abl constructs comprising the SH2 and KDs in vitro. We present a crystal structure of an SH2-KD construct bound to dasatinib, which contains the relevant inte...
The regulation of the activity of Abl and Src family tyrosine kinases is mediated by intramolecular ...
Protein tyrosine kinases of the Abl family have diverse roles in normal cellular regulation and driv...
The c-Abl protein-tyrosine kinase regulates diverse cellular signaling pathways involved in cell gro...
Constitutive activation of the non-receptor tyrosine kinase c-Abl (cellular Abelson tyrosine protein...
Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion onco...
SummaryChronic myelogenous leukemia (CML) is caused by the constitutively active tyrosine kinase Bcr...
<div><p>Regulation of the c-Abl (ABL1) tyrosine kinase is important because of its role in cellular ...
The activity of protein kinases is regulated by multiple molecular mechanisms, and their disruption ...
Abstractc-Abl is normally regulated by an autoinhibitory mechanism, the disruption of which leads to...
The tyrosine kinase c-Abl is inactivated by interactions made by its SH3 and SH2 domains with the di...
Abstractc-Abl is normally regulated by an autoinhibitory mechanism, the disruption of which leads to...
<p><b>A</b> The c-Abl isoform Ib is characterized by myristoylation (Myr) on Gly-2 of the N-terminal...
Regulation of the c-Abl (ABL1) tyrosine kinase is important because of its role in cellular signalin...
SummaryThe regulation of the activity of Abl and Src family tyrosine kinases is mediated by intramol...
SummaryThe regulation of the activity of Abl and Src family tyrosine kinases is mediated by intramol...
The regulation of the activity of Abl and Src family tyrosine kinases is mediated by intramolecular ...
Protein tyrosine kinases of the Abl family have diverse roles in normal cellular regulation and driv...
The c-Abl protein-tyrosine kinase regulates diverse cellular signaling pathways involved in cell gro...
Constitutive activation of the non-receptor tyrosine kinase c-Abl (cellular Abelson tyrosine protein...
Constitutive activation of the non-receptor tyrosine kinase c-Abl (Abl1) in the Bcr-Abl1 fusion onco...
SummaryChronic myelogenous leukemia (CML) is caused by the constitutively active tyrosine kinase Bcr...
<div><p>Regulation of the c-Abl (ABL1) tyrosine kinase is important because of its role in cellular ...
The activity of protein kinases is regulated by multiple molecular mechanisms, and their disruption ...
Abstractc-Abl is normally regulated by an autoinhibitory mechanism, the disruption of which leads to...
The tyrosine kinase c-Abl is inactivated by interactions made by its SH3 and SH2 domains with the di...
Abstractc-Abl is normally regulated by an autoinhibitory mechanism, the disruption of which leads to...
<p><b>A</b> The c-Abl isoform Ib is characterized by myristoylation (Myr) on Gly-2 of the N-terminal...
Regulation of the c-Abl (ABL1) tyrosine kinase is important because of its role in cellular signalin...
SummaryThe regulation of the activity of Abl and Src family tyrosine kinases is mediated by intramol...
SummaryThe regulation of the activity of Abl and Src family tyrosine kinases is mediated by intramol...
The regulation of the activity of Abl and Src family tyrosine kinases is mediated by intramolecular ...
Protein tyrosine kinases of the Abl family have diverse roles in normal cellular regulation and driv...
The c-Abl protein-tyrosine kinase regulates diverse cellular signaling pathways involved in cell gro...