All eukaryotic cells must segregate their chromosomes equally between two daughter cells at each division. This process needs to be robust, as errors in the form of loss or gain of genetic material have catastrophic effects on viability. Chromosomes are captured, aligned, and segregated to daughter cells via interaction with spindle microtubules mediated by the kinetochore. In Saccharomyces cerevisiae one microtubule attaches to each kinetochore, requiring extreme processivity from this single connection. The yeast Dam1 complex, an essential component of the outer kinetochore, forms rings around microtubules and in vitro recapitulates much of the functionality of a kinetochore-microtubule attachment. To understand the mechanism of the Dam1 ...
Kinetochores are large protein complexes that link sister chromatids to the spindle and transduce mi...
The coupling of kinetochores to dynamic spindle microtubules is crucial for chromosome positioning a...
In fission yeast centromeres cluster at the nuclear envelope in a region underlying the spindle pole...
All eukaryotic cells must segregate their chromosomes equally between two daughter cells at each div...
All eukaryotic cells must segregate their chromosomes equally between two daughter cells at each div...
ABSTRACT All eukaryotic cells must segregate their chromosomes equally between two daughter cells at...
All eukaryotic cells must equally segregate their chromosomes between two daughter cells each time t...
Thesis (Master's)--University of Washington, 2016-08Strong kinetochore-microtubule attachments are e...
In dividing cells, depolymerizing spindle microtubules move chromosomes by pulling at their kinetoch...
Thesis (Ph.D.)--University of Washington, 2014Chromosomes carry the genetic information that acts as...
Thesis (Ph.D.)--University of Washington, 2018Equal partitioning of replicated chromosomes during mi...
Thesis (Ph.D.)--University of Washington, 2018Equal partitioning of replicated chromosomes during mi...
Stable kinetochore-microtubule attachments are essential for equal division of chromosomes among dau...
Kinetochores are large protein complexes that link sister chromatids to the spindle and transduce mi...
Kinetochores are large protein complexes that link sister chromatids to the spindle and transduce mi...
Kinetochores are large protein complexes that link sister chromatids to the spindle and transduce mi...
The coupling of kinetochores to dynamic spindle microtubules is crucial for chromosome positioning a...
In fission yeast centromeres cluster at the nuclear envelope in a region underlying the spindle pole...
All eukaryotic cells must segregate their chromosomes equally between two daughter cells at each div...
All eukaryotic cells must segregate their chromosomes equally between two daughter cells at each div...
ABSTRACT All eukaryotic cells must segregate their chromosomes equally between two daughter cells at...
All eukaryotic cells must equally segregate their chromosomes between two daughter cells each time t...
Thesis (Master's)--University of Washington, 2016-08Strong kinetochore-microtubule attachments are e...
In dividing cells, depolymerizing spindle microtubules move chromosomes by pulling at their kinetoch...
Thesis (Ph.D.)--University of Washington, 2014Chromosomes carry the genetic information that acts as...
Thesis (Ph.D.)--University of Washington, 2018Equal partitioning of replicated chromosomes during mi...
Thesis (Ph.D.)--University of Washington, 2018Equal partitioning of replicated chromosomes during mi...
Stable kinetochore-microtubule attachments are essential for equal division of chromosomes among dau...
Kinetochores are large protein complexes that link sister chromatids to the spindle and transduce mi...
Kinetochores are large protein complexes that link sister chromatids to the spindle and transduce mi...
Kinetochores are large protein complexes that link sister chromatids to the spindle and transduce mi...
The coupling of kinetochores to dynamic spindle microtubules is crucial for chromosome positioning a...
In fission yeast centromeres cluster at the nuclear envelope in a region underlying the spindle pole...