TNF-alpha is a mediator of insulin resistance in sepsis, obesity, and type 2 diabetes and is known to impair insulin signaling in adipocytes. Akt (protein kinase B) is a crucial signaling mediator for insulin. In the present study we examined the posttranslational mechanisms by which short-term (<6-h) exposure of 3T3-L1 adipocytes to TNF-alpha decreases Akt levels. TNF-alpha treatment both increased the ubiquitination of Akt and decreased its protein level. The decrease in protein was associated with the presence of an (immunoreactive) Akt fragment after TNF-alpha treatment, indicative of Akt cleavage. The broad-spectrum caspase inhibitor t-butoxycarbonyl-Asp(O-Me)-fluoromethyl ketone markedly suppressed these effects of TNF-alpha. The c...
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF rece...
Tumor necrosis factor-alpha (TNFα) is a multifunctional cytokine which exerts a myriad of biological...
Adipose tissue is a key regulator of energy homeostasis. Diseases with an increase or decrease in ad...
TNF-alpha is a mediator of insulin resistance in sepsis, obesity, and type 2 diabetes and is known t...
BACKGROUND: Elevation of plasma free fatty acids as a principal aspect of type 2 diabetes maintains ...
Background: Elevation of plasma free fatty acids as a principal aspect of type 2 diabetes maintains ...
AbstractFas (CD95) belongs to the superfamily of the tumor necrosis factor (TNF) receptors. Besides ...
SummaryElevated levels of tumor necrosis factor (TNFα) are implicated in the development of insulin ...
Adipose tissue is a key regulator of energy metabolism and glucose homeostasis by promoting triglyce...
AbstractDyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic...
Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditi...
Introduction: Insulin resistance plays a major role in type 2 diabetes and obesity. In this disorder...
Aims/hypothesis: TNF-\u3b1 levels are increased in obesity and type 2 diabetes. The regulation of TN...
ABSTRACT AKT CONTROLS ADIPOCYTE FUNCTION AND SYSTEMIC METABOLISM Abigail L. Shearin Morris J. Birnba...
Insulin resistance is a cardinal feature of Type 2 Diabetes (T2D), which accompanied by lipid accumu...
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF rece...
Tumor necrosis factor-alpha (TNFα) is a multifunctional cytokine which exerts a myriad of biological...
Adipose tissue is a key regulator of energy homeostasis. Diseases with an increase or decrease in ad...
TNF-alpha is a mediator of insulin resistance in sepsis, obesity, and type 2 diabetes and is known t...
BACKGROUND: Elevation of plasma free fatty acids as a principal aspect of type 2 diabetes maintains ...
Background: Elevation of plasma free fatty acids as a principal aspect of type 2 diabetes maintains ...
AbstractFas (CD95) belongs to the superfamily of the tumor necrosis factor (TNF) receptors. Besides ...
SummaryElevated levels of tumor necrosis factor (TNFα) are implicated in the development of insulin ...
Adipose tissue is a key regulator of energy metabolism and glucose homeostasis by promoting triglyce...
AbstractDyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic...
Dyslipidemia and insulin resistance are commonly associated with catabolic or lipodystrophic conditi...
Introduction: Insulin resistance plays a major role in type 2 diabetes and obesity. In this disorder...
Aims/hypothesis: TNF-\u3b1 levels are increased in obesity and type 2 diabetes. The regulation of TN...
ABSTRACT AKT CONTROLS ADIPOCYTE FUNCTION AND SYSTEMIC METABOLISM Abigail L. Shearin Morris J. Birnba...
Insulin resistance is a cardinal feature of Type 2 Diabetes (T2D), which accompanied by lipid accumu...
Tumor necrosis factor (TNF)-alpha inhibits insulin signaling through stimulation of the p55 TNF rece...
Tumor necrosis factor-alpha (TNFα) is a multifunctional cytokine which exerts a myriad of biological...
Adipose tissue is a key regulator of energy homeostasis. Diseases with an increase or decrease in ad...