Add to ORKGMany bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. During leptospirosis, individuals are infected by contact with Leptospira-containing animal urine-contaminated water. The spirochetes invade internal organs after septicemia to cause disease aggravation, but the mechanism of leptospiral excretion and spreading remains unknown. Here, we demonstrated that Leptospira interrogans entered human/mouse endothelial and epithelial cells and fibroblasts by caveolae/integrin-β1-PI3K/FAK-mediated microfilament-dependent endocytosis to form Leptospira (Lep)-vesicles that did not fuse with lysosomes. Lep-vesicles recruited Rab5/Rab11 and Sec/Exo-SNARE proteins in endocytic recycling and vesicular transport...
Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents ca...
<div><p><i>Leptospira (L.) interrogans</i> are bacteria responsible for a worldwide reemerging zoono...
Background. Leptospirosis is a global zoonotic infectious disease caused by Leptospira interrogans. ...
Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. ...
Pathogenic Leptospira transmits from animals to humans, causing the zoonotic life-threatening infect...
International audienceLeptospira interrogans are pathogenic bacteria responsible for leptospirosis, ...
Abstract Background Leptospira interrogans is a pathogenic, spirochetal bacterium that is responsibl...
Pathogenic spirochetes of the genus Leptospira are a major cause of human zoonotic infectious diseas...
Cell adhesion molecules (CAMs) are surface receptors present in eukaryotic cells that mediate cell-c...
Bacterial pathogens have evolved multiple strategies to disassemble epithelial cell apical junctiona...
Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic members of...
International audienceLeptospira (L.) interrogans are bacteria responsible for a worldwide reemergin...
Leptospirosis is a neglected infectious disease with global impact on both humans and animals. The i...
<div><p>Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic me...
The goal of this study was to characterize how natural routes of infection affect the kinetics of pa...
Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents ca...
<div><p><i>Leptospira (L.) interrogans</i> are bacteria responsible for a worldwide reemerging zoono...
Background. Leptospirosis is a global zoonotic infectious disease caused by Leptospira interrogans. ...
Many bacterial pathogens can cause septicemia and spread from the bloodstream into internal organs. ...
Pathogenic Leptospira transmits from animals to humans, causing the zoonotic life-threatening infect...
International audienceLeptospira interrogans are pathogenic bacteria responsible for leptospirosis, ...
Abstract Background Leptospira interrogans is a pathogenic, spirochetal bacterium that is responsibl...
Pathogenic spirochetes of the genus Leptospira are a major cause of human zoonotic infectious diseas...
Cell adhesion molecules (CAMs) are surface receptors present in eukaryotic cells that mediate cell-c...
Bacterial pathogens have evolved multiple strategies to disassemble epithelial cell apical junctiona...
Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic members of...
International audienceLeptospira (L.) interrogans are bacteria responsible for a worldwide reemergin...
Leptospirosis is a neglected infectious disease with global impact on both humans and animals. The i...
<div><p>Leptospirosis is a globally distributed bacterial infectious disease caused by pathogenic me...
The goal of this study was to characterize how natural routes of infection affect the kinetics of pa...
Leptospira (L.) interrogans are bacteria responsible for a worldwide reemerging zoonosis. Rodents ca...
<div><p><i>Leptospira (L.) interrogans</i> are bacteria responsible for a worldwide reemerging zoono...
Background. Leptospirosis is a global zoonotic infectious disease caused by Leptospira interrogans. ...