Add to ORKGHeart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF cases are attributable to monogenic cardiomyopathies and existing genome-wide association studies (GWAS) have yielded only limited insights, leaving the observed heritability of HF largely unexplained. We report results from a GWAS meta-analysis of HF comprising 47,309 cases and 930,014 controls. Twelve independent variants at 11 genomic loci are associated with HF, all of which demonstrate one or more associations with coronary artery disease (CAD), atrial fibrillation, or reduced left ventricular function, suggesting shared genetic aetiology. Functional analysis of non-CAD-associated loci implicate genes involved in cardiac development (MY...
A genome-wide association study identifies two loci associated with heart failure due t
Aims: Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurren...
The genetics of heart failure is complex. In familial cases of cardiomyopathy, where mutations of la...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF...
Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incomp...
Purpose of reviewIn contrast to many other human diseases, the use of genome-wide association studie...
Despite the striking advances in medical and surgical therapy, the morbidity, mortality, and economi...
Heart failure (HF) is a complex clinical syndrome resulting from structural or functional impairment...
AbstractHeart failure (HF) occurs when the cardiac output, no longer compensated by endogenous mecha...
A genome-wide association study identifies two loci associated with heart failure due t
Aims: Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurren...
The genetics of heart failure is complex. In familial cases of cardiomyopathy, where mutations of la...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF...
Heart failure (HF) is a leading cause of morbidity and mortality worldwide. A small proportion of HF...
Heart failure (HF) is a morbid and heritable disorder for which the biological mechanisms are incomp...
Purpose of reviewIn contrast to many other human diseases, the use of genome-wide association studie...
Despite the striking advances in medical and surgical therapy, the morbidity, mortality, and economi...
Heart failure (HF) is a complex clinical syndrome resulting from structural or functional impairment...
AbstractHeart failure (HF) occurs when the cardiac output, no longer compensated by endogenous mecha...
A genome-wide association study identifies two loci associated with heart failure due t
Aims: Dilated cardiomyopathy (DCM) is a major cause of heart failure with a high familial recurren...
The genetics of heart failure is complex. In familial cases of cardiomyopathy, where mutations of la...