Add to ORKGObjectiveWe aimed to determine the effect of elevated BMI over time on the progression to type 1 diabetes in youth.Research design and methodsWe studied 1,117 children in the TrialNet Pathway to Prevention cohort (autoantibody-positive relatives of patients with type 1 diabetes). Longitudinally accumulated BMI above the 85th age- and sex-adjusted percentile generated a cumulative excess BMI (ceBMI) index. Recursive partitioning and multivariate analyses yielded sex- and age-specific ceBMI thresholds for greatest type 1 diabetes risk.ResultsHigher ceBMI conferred significantly greater risk of progressing to type 1 diabetes. The increased diabetes risk occurred at lower ceBMI values in children <12 years of age compared with older subjects...
Background: The incidence rate of Type 1 Diabetes (T1DM) is increasing in line with the obesity epid...
Aims/hypothesis The aim of this work was to examine the relationship between family history of type ...
Objective:Type 1 diabetes and obesity has increased in childhood. We therefore tested the hypothesis...
ObjectiveWe aimed to determine the effect of elevated BMI over time on the progression to type 1 dia...
Objective: Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive...
The prevalence of childhood overweight and obesity has risen during the last 30 years, not only in c...
Aims/hypothesis: We aimed to evaluate the relationship between childhood growth measures and risk of...
Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This...
There is extensive literature on the etiology of Type 1 diabetes mellitus (T1DM). T1DM is a disease ...
Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This...
Objective: To evaluate the relation between excess body mass index (BMI)-years, a measure of the deg...
Objective: Increased weight gain has been reported prior to disease onset (accelerator hypothesis) a...
We examined the prospective association of childhood BMI z-score and BMI categories (normal or overw...
AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabete...
In 2001, Wilkin (1) postulated that type1 and type 2 diabetes are mostly thesame disorder, only dist...
Background: The incidence rate of Type 1 Diabetes (T1DM) is increasing in line with the obesity epid...
Aims/hypothesis The aim of this work was to examine the relationship between family history of type ...
Objective:Type 1 diabetes and obesity has increased in childhood. We therefore tested the hypothesis...
ObjectiveWe aimed to determine the effect of elevated BMI over time on the progression to type 1 dia...
Objective: Sustained excess BMI increases the risk of type 1 diabetes (T1D) in autoantibody-positive...
The prevalence of childhood overweight and obesity has risen during the last 30 years, not only in c...
Aims/hypothesis: We aimed to evaluate the relationship between childhood growth measures and risk of...
Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This...
There is extensive literature on the etiology of Type 1 diabetes mellitus (T1DM). T1DM is a disease ...
Increased growth in early childhood has been suggested to increase the risk of type 1 diabetes. This...
Objective: To evaluate the relation between excess body mass index (BMI)-years, a measure of the deg...
Objective: Increased weight gain has been reported prior to disease onset (accelerator hypothesis) a...
We examined the prospective association of childhood BMI z-score and BMI categories (normal or overw...
AIMS/HYPOTHESIS: High birthweight and increased childhood growth are risk factors for type 1 diabete...
In 2001, Wilkin (1) postulated that type1 and type 2 diabetes are mostly thesame disorder, only dist...
Background: The incidence rate of Type 1 Diabetes (T1DM) is increasing in line with the obesity epid...
Aims/hypothesis The aim of this work was to examine the relationship between family history of type ...
Objective:Type 1 diabetes and obesity has increased in childhood. We therefore tested the hypothesis...