Signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. Here, we find that when activated G protein-coupled receptors (GPCRs) fail to undergo BBSome-mediated retrieval from cilia back into the cell, these GPCRs concentrate into membranous buds at the tips of cilia before release into extracellular vesicles named ectosomes. Unexpectedly, actin and the actin regulators drebrin and myosin 6 mediate ectosome release from the tip of cilia. Mirroring signal-dependent retrieval, signal-dependent ectocytosis is a selective and effective process that removes activated signaling molecules from cilia. Congruently, ectocytosis compensates for BBSome defects as ectocytic removal of GPR161, a negative regulator ...
Vertebrate hedgehog signaling is coordinated by the differential localization of the receptors patch...
Primary cilia are polarized organelles that allow detection of extracellular signals such as Hedgeho...
During development, the Hedgehog (Hh) signaling pathway controls growth, cell fate decisions and mor...
Signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. H...
Dynamic changes in membrane protein composition of the primary cilium are central to development and...
ABSTRACT Regulated trafficking of G-protein coupled receptors (GPCRs) controls cilium-based signalin...
Regulated trafficking of G protein-coupled receptors (GPCRs) controls cilium-based signaling pathway...
SummaryThe primary cilium is required for Sonic hedgehog (Shh) signaling in vertebrates. In contrast...
ABSTRACT The primary cilium is a signaling compartment that interprets Hedgehog signals through chan...
Cilia are key subcellular organelles for the coordination of signaling pathways. The importance of c...
The primary cilium is a signaling compartment that interprets Hedgehog signals through changes of it...
SummaryVertebrate hedgehog signaling is coordinated by the differential localization of the receptor...
The Hedgehog pathway, critical to vertebrate development, is organized in primary cilia. Activation ...
Hedgehog pathway components and select G protein-coupled receptors (GPCRs) localize to the primary c...
Primary cilia are solitary organelles that emanate from the plasma membrane during growth arrest in ...
Vertebrate hedgehog signaling is coordinated by the differential localization of the receptors patch...
Primary cilia are polarized organelles that allow detection of extracellular signals such as Hedgeho...
During development, the Hedgehog (Hh) signaling pathway controls growth, cell fate decisions and mor...
Signaling receptors dynamically exit cilia upon activation of signaling pathways such as Hedgehog. H...
Dynamic changes in membrane protein composition of the primary cilium are central to development and...
ABSTRACT Regulated trafficking of G-protein coupled receptors (GPCRs) controls cilium-based signalin...
Regulated trafficking of G protein-coupled receptors (GPCRs) controls cilium-based signaling pathway...
SummaryThe primary cilium is required for Sonic hedgehog (Shh) signaling in vertebrates. In contrast...
ABSTRACT The primary cilium is a signaling compartment that interprets Hedgehog signals through chan...
Cilia are key subcellular organelles for the coordination of signaling pathways. The importance of c...
The primary cilium is a signaling compartment that interprets Hedgehog signals through changes of it...
SummaryVertebrate hedgehog signaling is coordinated by the differential localization of the receptor...
The Hedgehog pathway, critical to vertebrate development, is organized in primary cilia. Activation ...
Hedgehog pathway components and select G protein-coupled receptors (GPCRs) localize to the primary c...
Primary cilia are solitary organelles that emanate from the plasma membrane during growth arrest in ...
Vertebrate hedgehog signaling is coordinated by the differential localization of the receptors patch...
Primary cilia are polarized organelles that allow detection of extracellular signals such as Hedgeho...
During development, the Hedgehog (Hh) signaling pathway controls growth, cell fate decisions and mor...