Add to ORKGObjectiveThe goal of this study was to investigate the effect of progranulin insufficiency on extracellular vesicles (EVs), a heterogeneous population of vesicles that may contribute to progression of neurodegenerative disease. Loss-of-function mutations in progranulin (GRN) are a major cause of frontotemporal dementia (FTD), and brains from GRN carriers with FTD (FTD-GRN) exhibit signs of lysosomal dysfunction. Lysosomal dysfunction may induce compensatory increases in secretion of exosomes, EVs secreted from the endolysosomal system, so we hypothesized that progranulin insufficiency would increase EV levels in the brain.MethodsWe analyzed levels and protein contents of brain EVs from Grn-/- mice, which model the lysosomal abnormalities of...
Abstract Background Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to fr...
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotempora...
Abstract Mutations resulting in haploinsufficiency of progranulin (PGRN) cause fronto...
Summary: Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin (PGRN),...
Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in social and em...
The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causal...
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lys...
Frontotemporal lobar degeneration (FTLD) is a devastating, late-onset neurodegenerative disorder tha...
Abstract Background Loss of function mutations in progranulin (GRN) are a major cause of frontotempo...
Heterozygous loss-of-function mutations in the progranulin (GRN) gene and the resulting reduction of...
Loss-of-function mutations in progranulin (GRN) that result in haploinsufficiency of the progranulin...
Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotempor...
Frontotemporal dementia (FTD) is a common early-onset dementia caused by heterozygous mutations in t...
Abstract Frontotemporal lobar degeneration (FTLD) causes a spectrum of clinical prese...
Deficient progranulin levels cause dose-dependent neurological syndromes: haploinsufficiency leads t...
Abstract Background Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to fr...
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotempora...
Abstract Mutations resulting in haploinsufficiency of progranulin (PGRN) cause fronto...
Summary: Loss-of-function mutations in the progranulin gene (GRN), which encodes progranulin (PGRN),...
Frontotemporal dementia (FTD) is a neurodegenerative disease with hallmark deficits in social and em...
The discovery that heterozygous and homozygous mutations in the gene encoding progranulin are causal...
GRN mutations cause frontotemporal dementia (GRN-FTD) due to deficiency in progranulin (PGRN), a lys...
Frontotemporal lobar degeneration (FTLD) is a devastating, late-onset neurodegenerative disorder tha...
Abstract Background Loss of function mutations in progranulin (GRN) are a major cause of frontotempo...
Heterozygous loss-of-function mutations in the progranulin (GRN) gene and the resulting reduction of...
Loss-of-function mutations in progranulin (GRN) that result in haploinsufficiency of the progranulin...
Loss-of-function mutations in progranulin (GRN) are a major autosomal dominant cause of frontotempor...
Frontotemporal dementia (FTD) is a common early-onset dementia caused by heterozygous mutations in t...
Abstract Frontotemporal lobar degeneration (FTLD) causes a spectrum of clinical prese...
Deficient progranulin levels cause dose-dependent neurological syndromes: haploinsufficiency leads t...
Abstract Background Heterozygous loss-of-function mutations in the progranulin gene (GRN) lead to fr...
Null mutations in the progranulin gene (PGRN) have been identified as a major cause of frontotempora...
Abstract Mutations resulting in haploinsufficiency of progranulin (PGRN) cause fronto...