Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a common event in acute liver injury/failure and chronic liver disease. Even though hepatic ammonia levels are potential predictive factors of patient outcome, easy and inexpensive methods aiming at the detection of liver ammonia accumulation in the clinical setting remain unavailable. Thus, herein we have developed a morphological method, based on the utilization of Nessler´s reagent, to accurately and precisely detect the accumulation of ammonia in biological tissue. We have validated our method against a commercially available kit in mouse tissue samples and, by using this modified method, we have confirmed the hepatic accumulation of ammonia in clini...
Ammonia reduction is the target for therapy of hepatic encephalopathy, but lack of quantitative data...
Background & AimsRecently, spatial-temporal/metabolic mathematical models have been established that...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...
Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a common eve...
<div><p>Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a co...
Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a common eve...
By the end of the nineteenth century, ammonia had been identified as the main factor responsible for...
Blood ammonia levels in patients with various liver diseases were determined quantitatively by a sim...
International audienceThe impairment of hepatic metabolism due to liver injury has high systemic rel...
Patients with liver disease have reduced urea synthesis capacity resulting in reduced capacity to de...
This thesis is concerned with the use of ammoniumsalts in the diagnosis of diseases of the liver and...
This thesis contains four sections: overview, methodology, in vivo, physiology and pathology. The fi...
David G Levitt,1 Michael D Levitt2 1Department of Integrative Biology and Physiology, University of ...
EDITORIAL SYNOPSIS The relation between ammonia intoxication and liver disease is not clear. Ammonia...
BACKGROUND: Portal hypertension leads to the formation of portosystemic collateral veins in liver ci...
Ammonia reduction is the target for therapy of hepatic encephalopathy, but lack of quantitative data...
Background & AimsRecently, spatial-temporal/metabolic mathematical models have been established that...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...
Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a common eve...
<div><p>Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a co...
Hyperammonemia is a metabolic condition characterized by elevated levels of ammonia and a common eve...
By the end of the nineteenth century, ammonia had been identified as the main factor responsible for...
Blood ammonia levels in patients with various liver diseases were determined quantitatively by a sim...
International audienceThe impairment of hepatic metabolism due to liver injury has high systemic rel...
Patients with liver disease have reduced urea synthesis capacity resulting in reduced capacity to de...
This thesis is concerned with the use of ammoniumsalts in the diagnosis of diseases of the liver and...
This thesis contains four sections: overview, methodology, in vivo, physiology and pathology. The fi...
David G Levitt,1 Michael D Levitt2 1Department of Integrative Biology and Physiology, University of ...
EDITORIAL SYNOPSIS The relation between ammonia intoxication and liver disease is not clear. Ammonia...
BACKGROUND: Portal hypertension leads to the formation of portosystemic collateral veins in liver ci...
Ammonia reduction is the target for therapy of hepatic encephalopathy, but lack of quantitative data...
Background & AimsRecently, spatial-temporal/metabolic mathematical models have been established that...
Background/Aims: Ammonia reduction is the target for therapy of hepatic encephalopathy (HE) but lack...