Add to ORKGObjectiveAging is associated with impaired insulin sensitivity and increased prevalence of type 2 diabetes. However, it remains unclear whether aging-associated insulin resistance is due to increased adiposity or other age-related factors. To address this question, the impact of aging on insulin sensitivity was investigated independently of changes in body composition.MethodsCohorts of mice aged 4 to 8 months ("young") and 18 to 27 months ("aged") exhibiting similar body composition were characterized for glucose metabolism on chow and high-fat diets. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamp analyses. The relationship between aging and insulin resistance in humans was investigated in 1,250 nondiabetic ...
Aging is associated with a decline in peripheral insulin sensitivity and an increased risk of impair...
<p>(A) Glucose tolerance tests (GTT) were performed in different groups of mice at different ages (4...
Insulin resistance (IR) is the hallmark of type 2 diabetes (T2DM) and can precede its onset for many...
ObjectiveAging is associated with impaired insulin sensitivity and increased prevalence of type 2 di...
OBJECTIVE: Aging is associated with impaired insulin sensitivity and increased prevalence of type 2 ...
Insulin resistance and increased fat mass (FM) are common in human aging. We aimed to investigate th...
Human life expectancy is increasing faster lately and, consequently, the number of patients with age...
OBJECTIVE-Although advanced age is a risk factor for type 2 diabetes, a clear understanding of the c...
Diet modulates the development of insulin resistance during aging. This includes tissue-specific alt...
ajpendo.00366.2002.—Glucose tolerance progressively declines with age, and there is a high prevalenc...
moters of diabetic complications, form abundantly in heated foods and are ingested in bioreactive fo...
Abstract Background The skeletal muscle plays a central role in glucose homeostasis through the upta...
UnrestrictedAging is characterized by obesity, insulin resistance, glucose intolerance and an increa...
<p>A. RIIβ<sup>−/−</sup> blood glucose levels were slightly lower than WT for both old males and fem...
Yellow KK mice carrying the \u27yellow obese\u27 gene Ay are a well established polygenic model for ...
Aging is associated with a decline in peripheral insulin sensitivity and an increased risk of impair...
<p>(A) Glucose tolerance tests (GTT) were performed in different groups of mice at different ages (4...
Insulin resistance (IR) is the hallmark of type 2 diabetes (T2DM) and can precede its onset for many...
ObjectiveAging is associated with impaired insulin sensitivity and increased prevalence of type 2 di...
OBJECTIVE: Aging is associated with impaired insulin sensitivity and increased prevalence of type 2 ...
Insulin resistance and increased fat mass (FM) are common in human aging. We aimed to investigate th...
Human life expectancy is increasing faster lately and, consequently, the number of patients with age...
OBJECTIVE-Although advanced age is a risk factor for type 2 diabetes, a clear understanding of the c...
Diet modulates the development of insulin resistance during aging. This includes tissue-specific alt...
ajpendo.00366.2002.—Glucose tolerance progressively declines with age, and there is a high prevalenc...
moters of diabetic complications, form abundantly in heated foods and are ingested in bioreactive fo...
Abstract Background The skeletal muscle plays a central role in glucose homeostasis through the upta...
UnrestrictedAging is characterized by obesity, insulin resistance, glucose intolerance and an increa...
<p>A. RIIβ<sup>−/−</sup> blood glucose levels were slightly lower than WT for both old males and fem...
Yellow KK mice carrying the \u27yellow obese\u27 gene Ay are a well established polygenic model for ...
Aging is associated with a decline in peripheral insulin sensitivity and an increased risk of impair...
<p>(A) Glucose tolerance tests (GTT) were performed in different groups of mice at different ages (4...
Insulin resistance (IR) is the hallmark of type 2 diabetes (T2DM) and can precede its onset for many...