Add to ORKGAging is associated with loss of tissue mass and a decline in adult stem cell function in many tissues. In contrast, aging in the prostate is associated with growth-related diseases including benign prostatic hyperplasia (BPH). Surprisingly, the effects of aging on prostate epithelial cells have not been established. Here we find that organoid-forming progenitor activity of mouse prostate basal and luminal cells is maintained with age. This is caused by an age-related expansion of progenitor-like luminal cells that share features with human prostate luminal progenitor cells. The increase in luminal progenitor cells may contribute to greater risk for growth-related disease in the aging prostate. Importantly, we demonstrate expansion of human...
Background: Prostate cancer is the second most frequent cancer among males worldwide, and most patie...
Prostate epithelial basal cells are highly plastic in their luminal differentiation capability. Basa...
Prostate epithelial basal cells are highly plastic in their luminal differentiation capability. Basa...
Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissu...
Many organs experience a loss of tissue mass and a decline in regenerative capacity during aging. In...
Stem and progenitor cells of the adult prostate epithelium have historically been believed to reside...
Advancing age is associated with substantial increases in the incidence rates of common diseases aff...
Advancing age is associated with substantial increases in the incidence rates of common diseases aff...
Maintenance of the prostatic epithelial cell compartment is ensured by proliferation of adult epithe...
Maintenance of the prostatic epithelial cell compartment is ensured by proliferation of adult epithe...
Abstract Background Prostate cancer is the second most frequent cancer among males worldwide, and mo...
The prostate is a glandular epithelium composed of basal, luminal and neuroendocrine cells that orig...
The direct relationship between the aging process and the incidence and prevalence of both benign pr...
Benign prostatic hyperplasia (BPH) is characterized by increased tissue mass in the transition zone ...
BACKGROUND: Prostate cancer is the second most frequent cancer among males worldwide, and most patie...
Background: Prostate cancer is the second most frequent cancer among males worldwide, and most patie...
Prostate epithelial basal cells are highly plastic in their luminal differentiation capability. Basa...
Prostate epithelial basal cells are highly plastic in their luminal differentiation capability. Basa...
Aging is associated with loss of tissue mass and a decline in adult stem cell function in many tissu...
Many organs experience a loss of tissue mass and a decline in regenerative capacity during aging. In...
Stem and progenitor cells of the adult prostate epithelium have historically been believed to reside...
Advancing age is associated with substantial increases in the incidence rates of common diseases aff...
Advancing age is associated with substantial increases in the incidence rates of common diseases aff...
Maintenance of the prostatic epithelial cell compartment is ensured by proliferation of adult epithe...
Maintenance of the prostatic epithelial cell compartment is ensured by proliferation of adult epithe...
Abstract Background Prostate cancer is the second most frequent cancer among males worldwide, and mo...
The prostate is a glandular epithelium composed of basal, luminal and neuroendocrine cells that orig...
The direct relationship between the aging process and the incidence and prevalence of both benign pr...
Benign prostatic hyperplasia (BPH) is characterized by increased tissue mass in the transition zone ...
BACKGROUND: Prostate cancer is the second most frequent cancer among males worldwide, and most patie...
Background: Prostate cancer is the second most frequent cancer among males worldwide, and most patie...
Prostate epithelial basal cells are highly plastic in their luminal differentiation capability. Basa...
Prostate epithelial basal cells are highly plastic in their luminal differentiation capability. Basa...