Central nervous system neurons, like retinal ganglion cells, often fail to regenerate their axons and die following axonal injury. A complete understanding of cellular dynamics in injured neurons is necessary to identify critical regulators of degeneration and to develop therapies for survival and regeneration. Although extensive efforts have been made to dissect the transcriptomic and genetic changes in these neurons, less headway has been made into understanding protein dynamics, the effectors of cellular responses.In this dissertation, I begin by reviewing the literature of regulators of neuronal regeneration and mechanisms underlying regenerative failure. Insights from disease point towards axonal transport failure as a unifying hypothe...
Using proteomics, We investigated the temporal expression profiles of proteins in rat sciatic nerve ...
Locally generating new proteins in subcellular regions provides means to spatially and temporally mo...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...
Central nervous system neurons, like retinal ganglion cells, often fail to regenerate their axons an...
Many neurons in the adult central nervous system, including retinal ganglion cells (RGCs), degenerat...
Molecular Discovery for Optic Nerve Regeneration (Goldberg, Benowitz and Cline labs): The aim of th...
The most prominent fast transported proteins conveyed along the axons of retinal ganglion cells and ...
SummaryNeurons differ in their responses to injury, but the underlying mechanisms remain poorly unde...
Protein synthesis in dendrites has become an accepted cellular mechanism that contributes to activit...
Retinal ganglion cells (RGCs) die after optic nerve trauma or in degenerative disease. However, acut...
My research focuses on understanding the mechanisms by which peripheral nervous system (PNS) neurons...
Recent studies have begun to focus on the signals that regulate axonal protein synthesis and the fun...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...
Neurons connect to their remote targets via axons, which usually survive for the lifetime of an orga...
A major reason why central nervous system (CNS) trauma and many neurodegenerative diseases demonstra...
Using proteomics, We investigated the temporal expression profiles of proteins in rat sciatic nerve ...
Locally generating new proteins in subcellular regions provides means to spatially and temporally mo...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...
Central nervous system neurons, like retinal ganglion cells, often fail to regenerate their axons an...
Many neurons in the adult central nervous system, including retinal ganglion cells (RGCs), degenerat...
Molecular Discovery for Optic Nerve Regeneration (Goldberg, Benowitz and Cline labs): The aim of th...
The most prominent fast transported proteins conveyed along the axons of retinal ganglion cells and ...
SummaryNeurons differ in their responses to injury, but the underlying mechanisms remain poorly unde...
Protein synthesis in dendrites has become an accepted cellular mechanism that contributes to activit...
Retinal ganglion cells (RGCs) die after optic nerve trauma or in degenerative disease. However, acut...
My research focuses on understanding the mechanisms by which peripheral nervous system (PNS) neurons...
Recent studies have begun to focus on the signals that regulate axonal protein synthesis and the fun...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...
Neurons connect to their remote targets via axons, which usually survive for the lifetime of an orga...
A major reason why central nervous system (CNS) trauma and many neurodegenerative diseases demonstra...
Using proteomics, We investigated the temporal expression profiles of proteins in rat sciatic nerve ...
Locally generating new proteins in subcellular regions provides means to spatially and temporally mo...
Axon injury and degeneration is a common consequence of diverse neurological conditions including mu...