The rest-frame UV emission from massive stars contains a wealth of information about the physical nature and conditions of star formation in galaxies. Using studies of the rest-frame UV, the past decade has witnessed the beginning of knowledge about the existence and properties of galaxies during the first few billion years after the Big Bang. This period of history corresponds to the formation of the first stars, the rapid formation of galaxy stellar populations, the reionization of the IGM, the production and dissemination of heavy elements, and the formation of the first black holes. Massive stars in these galaxies drive all of these events, and their light dominates the spectral energy distributions of galaxies. As we look to the 2020s,...