Add to ORKGTarget identification is a core challenge in chemical genetics. Here we use chemical similarity to computationally predict the targets of 586 compounds that were active in a zebrafish behavioral assay. Among 20 predictions tested, 11 compounds had activities ranging from 1 nM to 10,000 nM on the predicted targets. The roles of two of these targets were tested in the original zebrafish phenotype. Prediction of targets from chemotype is rapid and may be generally applicable
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molec...
<p>a) 4% of the 5760 compounds screened affected zebrafish embryos. 19% of the active compounds caus...
The larval zebrafish has emerged asa vertebrate model system amenable to small molecule screens for ...
Target identification is a core challenge in chemical genetics. Here we use chemical similarity to p...
Target identification is a core challenge in chemical genetics. Here we use chemical similarity to p...
Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behav...
Many psychiatric drugs modulate the nervous system through multitarget mechanisms. However, systemat...
Functional chemicals are very useful tools for molecular biology studies. Due to its small size, lar...
Phenotypic screens can identify molecules that are at once penetrant and active on the integrated ci...
In-vivo phenotypic screening in larval zebrafish has shown much promise for neuroactive drug discove...
Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this...
Neuroactive compounds are crucial tools in drug discovery and neuroscience. However, discovering mec...
AbstractTarget based chemical screens are a mainstay of modern drug discovery, but the effectiveness...
Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migratio...
Phenotypic screens can identify molecules that are at once penetrant and active on the integrated ci...
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molec...
<p>a) 4% of the 5760 compounds screened affected zebrafish embryos. 19% of the active compounds caus...
The larval zebrafish has emerged asa vertebrate model system amenable to small molecule screens for ...
Target identification is a core challenge in chemical genetics. Here we use chemical similarity to p...
Target identification is a core challenge in chemical genetics. Here we use chemical similarity to p...
Most neuroactive drugs were discovered through unexpected behavioral observations. Systematic behav...
Many psychiatric drugs modulate the nervous system through multitarget mechanisms. However, systemat...
Functional chemicals are very useful tools for molecular biology studies. Due to its small size, lar...
Phenotypic screens can identify molecules that are at once penetrant and active on the integrated ci...
In-vivo phenotypic screening in larval zebrafish has shown much promise for neuroactive drug discove...
Target based chemical screens are a mainstay of modern drug discovery, but the effectiveness of this...
Neuroactive compounds are crucial tools in drug discovery and neuroscience. However, discovering mec...
AbstractTarget based chemical screens are a mainstay of modern drug discovery, but the effectiveness...
Phenotype-driven chemical screening in zebrafish for compounds that inhibit collective cell migratio...
Phenotypic screens can identify molecules that are at once penetrant and active on the integrated ci...
A major obstacle for the discovery of psychoactive drugs is the inability to predict how small molec...
<p>a) 4% of the 5760 compounds screened affected zebrafish embryos. 19% of the active compounds caus...
The larval zebrafish has emerged asa vertebrate model system amenable to small molecule screens for ...