Add to ORKGIntroductionApolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive impairment (MCI), and Alzheimer's disease in Whites, but have weaker and inconsistent effects reported in Latinos. We hypothesized that this heterogeneity is due to ancestry-specific genetic effects.MethodsWe investigated the associations of the APOE alleles with significant cognitive decline and MCI in 4183 Latinos, stratified by six Latino backgrounds, and explored whether the proportion of continental genetic ancestry (European, African, and Amerindian) modifies these associations.ResultsAPOE ε4 was associated with an increased risk of significant cognitive decline (odds ratio [OR] = 1.15, P-value = 0....
ObjectivesTo examine the effects of age and race on the association of apolipoprotein E (APOE) genot...
The presence of the apolipoprotein E4 (apo €4) allele significantly increases the risk of Alzheimer'...
African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other popul...
IntroductionApolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive im...
IntroductionThe APOEε4 allele is the single strongest genetic risk for late-onset Alzheimer's diseas...
In 2019, the United States Census revealed that Hispanics are the greatest minority group in the U.S...
The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The...
The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer's Dis...
Alzheimer’s disease (AD) disproportionately affects Hispanic individuals, who face about 1.5- fold m...
The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The...
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of environmental an...
Cognitive function such as reasoning, attention, memory, and language is strongly correlated with br...
INTRODUCTION: Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for an outcome...
OBJECTIVE: The relationship between the epsilon 4 allele of the apolipoprotein E gene (APOE-epsilon4...
Objectives: To reexamine the association between the apolipoprotein E ϵ4 allele (APOE ϵ4) and famili...
ObjectivesTo examine the effects of age and race on the association of apolipoprotein E (APOE) genot...
The presence of the apolipoprotein E4 (apo €4) allele significantly increases the risk of Alzheimer'...
African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other popul...
IntroductionApolipoprotein E (APOE) alleles are associated with cognitive decline, mild cognitive im...
IntroductionThe APOEε4 allele is the single strongest genetic risk for late-onset Alzheimer's diseas...
In 2019, the United States Census revealed that Hispanics are the greatest minority group in the U.S...
The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The...
The apoE4 isoform is associated with increased cholesterol, cardiovascular risk, and Alzheimer's Dis...
Alzheimer’s disease (AD) disproportionately affects Hispanic individuals, who face about 1.5- fold m...
The ApoE ε4 allele is the most significant genetic risk factor for late-onset Alzheimer disease. The...
Dementia is more prevalent in Blacks than in Whites, likely due to a combination of environmental an...
Cognitive function such as reasoning, attention, memory, and language is strongly correlated with br...
INTRODUCTION: Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for an outcome...
OBJECTIVE: The relationship between the epsilon 4 allele of the apolipoprotein E gene (APOE-epsilon4...
Objectives: To reexamine the association between the apolipoprotein E ϵ4 allele (APOE ϵ4) and famili...
ObjectivesTo examine the effects of age and race on the association of apolipoprotein E (APOE) genot...
The presence of the apolipoprotein E4 (apo €4) allele significantly increases the risk of Alzheimer'...
African descent populations have a lower Alzheimer disease risk from ApoE ε4 compared to other popul...