Add to ORKGGalectins (Gals) are evolutionarily conserved proteins that bind to β-galactoside containing glycans. Abnormal expression of Gals is associated with the development, progression, and metastasis of different types of cancer. Among the 11 Gals identified in humans, the roles of Gal-1 and Gal-3 have been extensively investigated in various tumors. Here, we summarize the roles of overly expressed Gal-1 and Gal-3 in the pathogenesis of hepatocellular carcinoma (HCC). The overexpression of Gal-1 and Gal-3 correlates with tumor growth, HCC cell migration and invasion, tumor aggressiveness, metastasis, and poor prognosis. A potentially promising future treatment strategy for HCC may include the combination of immunotherapy with Gal-1 inhibition. Ad...
Galectins are a group of proteins that bind β-galactosides through evolutionarily conserved sequence...
The incidence and mortality of cancer have increased over the past decades. Significant progress has...
Abstract Background Gastric cancer (GC) is characterized by the excessive deposition of extracellula...
Galectins (Gals) are evolutionarily conserved proteins that bind to β-galactoside containing glycans...
Hepatocellular carcinoma is one of the most common cancers worldwide. Despite several efforts to elu...
Hepatocellular carcinoma is one of the most common cancers worldwide. Despite several efforts to elu...
Galectin-1 (Gal1), a β-galactoside-binding protein abundantly expressed in tumor microenvironments, ...
Conference Theme: From basic research to precision medicineThis journal suppl. entitled: 24th Bienni...
Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing...
Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely lo...
Galectins are a large family of proteins which bind galactoside-containing glycans. Their role in ca...
The efficacy of cancer immunotherapy is limited, in part, by the multitude of immunosuppressive mech...
Changes in cell growth and metabolism are affected by the surrounding environmental factors to adapt...
The galectins are a family of proteins that are distributed widely in all living organisms. All of t...
Galectins are small unglycosylated soluble lectins distributed both inside and outside the cells. Th...
Galectins are a group of proteins that bind β-galactosides through evolutionarily conserved sequence...
The incidence and mortality of cancer have increased over the past decades. Significant progress has...
Abstract Background Gastric cancer (GC) is characterized by the excessive deposition of extracellula...
Galectins (Gals) are evolutionarily conserved proteins that bind to β-galactoside containing glycans...
Hepatocellular carcinoma is one of the most common cancers worldwide. Despite several efforts to elu...
Hepatocellular carcinoma is one of the most common cancers worldwide. Despite several efforts to elu...
Galectin-1 (Gal1), a β-galactoside-binding protein abundantly expressed in tumor microenvironments, ...
Conference Theme: From basic research to precision medicineThis journal suppl. entitled: 24th Bienni...
Galectins constitute an evolutionary conserved family that binds to β-galactosides. There is growing...
Pancreatic ductal adenocarcinoma (PDA) remains one of the most lethal tumor types, with extremely lo...
Galectins are a large family of proteins which bind galactoside-containing glycans. Their role in ca...
The efficacy of cancer immunotherapy is limited, in part, by the multitude of immunosuppressive mech...
Changes in cell growth and metabolism are affected by the surrounding environmental factors to adapt...
The galectins are a family of proteins that are distributed widely in all living organisms. All of t...
Galectins are small unglycosylated soluble lectins distributed both inside and outside the cells. Th...
Galectins are a group of proteins that bind β-galactosides through evolutionarily conserved sequence...
The incidence and mortality of cancer have increased over the past decades. Significant progress has...
Abstract Background Gastric cancer (GC) is characterized by the excessive deposition of extracellula...