The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) occurs in 1 of 4000 live births, and 60% to 70% of affected individuals have congenital heart disease, ranging from mild to severe. In our cohort of 1472 subjects with 22q11.2DS, a total of 62% (n=906) have congenital heart disease and 36% (n=326) of these have tetralogy of Fallot (TOF), comprising the largest subset of severe congenital heart disease in the cohort. To identify common genetic variants associated with TOF in individuals with 22q11.2DS, we performed a genome-wide association study using Affymetrix 6.0 array and imputed genotype data. In our cohort, TOF was significantly associated with a genotyped single-nucleotide polymorphism (rs12519770,...
Tetralogy of Fallot (TOF), (OMIM #187500) one of the first known congenital heart disease (CHDs) wit...
BackgroundPatients with repaired tetralogy of Fallot experience variable outcomes for reasons that a...
Background Tetralogy of Fallot (ToF), the most frequent cyanotic congenital heart disease, is associ...
Background-The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) oc...
Background - The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) ...
The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) occurs in 1 o...
We conducted a genome-wide association study to search for risk alleles associated with Tetralogy of...
RATIONALE: Familial recurrence studies provide strong evidence for a genetic component to the predis...
We conducted a genome-wide association study to search for risk alleles associated with Tetralogy of...
Tetralogy of Fallot (TOF) is one of the most common severe congenital heart malformations. Great pro...
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease (CHD). The understand...
Background: Tetralogy of Fallot (TOF) is a congenital conotruncal heart defect commonly found in DiG...
<div><p>Tetralogy of Fallot (TOF) is one of the most common severe congenital heart malformations. G...
Structural genetic changes, especially copy number variants (CNVs), represent a major source of gene...
Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease, occurring in...
Tetralogy of Fallot (TOF), (OMIM #187500) one of the first known congenital heart disease (CHDs) wit...
BackgroundPatients with repaired tetralogy of Fallot experience variable outcomes for reasons that a...
Background Tetralogy of Fallot (ToF), the most frequent cyanotic congenital heart disease, is associ...
Background-The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) oc...
Background - The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) ...
The 22q11.2 deletion syndrome (22q11.2DS; DiGeorge syndrome/velocardiofacial syndrome) occurs in 1 o...
We conducted a genome-wide association study to search for risk alleles associated with Tetralogy of...
RATIONALE: Familial recurrence studies provide strong evidence for a genetic component to the predis...
We conducted a genome-wide association study to search for risk alleles associated with Tetralogy of...
Tetralogy of Fallot (TOF) is one of the most common severe congenital heart malformations. Great pro...
Tetralogy of Fallot (TOF) is the most common cyanotic congenital heart disease (CHD). The understand...
Background: Tetralogy of Fallot (TOF) is a congenital conotruncal heart defect commonly found in DiG...
<div><p>Tetralogy of Fallot (TOF) is one of the most common severe congenital heart malformations. G...
Structural genetic changes, especially copy number variants (CNVs), represent a major source of gene...
Tetralogy of Fallot (TOF) is the most common form of cyanotic congenital heart disease, occurring in...
Tetralogy of Fallot (TOF), (OMIM #187500) one of the first known congenital heart disease (CHDs) wit...
BackgroundPatients with repaired tetralogy of Fallot experience variable outcomes for reasons that a...
Background Tetralogy of Fallot (ToF), the most frequent cyanotic congenital heart disease, is associ...