Malaria is an infectious disease which disproportionately effects children and pregnant women. These vulnerable populations are often excluded from clinical trials resulting in one-size-fits-all treatment regimens based on those established for a nonpregnant adult population. Pharmacokinetic/pharmacodynamic (PK/PD) models can be used to optimize dose selection as they define the drug exposure-response relationship. Additionally, these models are able to identify patient characteristics that cause alterations in the expected PK/PD profiles and through simulations can recommend changes to dosing which compensate for the differences. In this review, we examine how PK/PD models have been applied to optimize antimalarial dosing recommendations f...
Background: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment...
A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment o...
A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment o...
Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which we...
Malaria is a mosquito-borne infectious disease which affects humans and other animals. In 2016 the W...
Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which we...
Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite...
Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite...
Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite...
Malaria is one of the most important tropical diseases, with hundreds of millions of cases every yea...
Malaria is a preventable and treatable infection, yet every two minutes a child dies from the diseas...
© 2012 Dr. Kris Marinelli JamsenBackground: Population pharmacokinetic (PK) studies aim to character...
Abstract Background Mechanistic within-host models relating blood anti-malarial drug concentrations ...
Chemoprophylactics are a vital tool in the fight against malaria. They can be used to protect popula...
The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-relate...
Background: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment...
A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment o...
A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment o...
Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which we...
Malaria is a mosquito-borne infectious disease which affects humans and other animals. In 2016 the W...
Antimalarial drugs have usually been first deployed in areas of malaria endemicity at doses which we...
Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite...
Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite...
Mechanistic within-host models integrating blood anti-malarial drug concentrations with the parasite...
Malaria is one of the most important tropical diseases, with hundreds of millions of cases every yea...
Malaria is a preventable and treatable infection, yet every two minutes a child dies from the diseas...
© 2012 Dr. Kris Marinelli JamsenBackground: Population pharmacokinetic (PK) studies aim to character...
Abstract Background Mechanistic within-host models relating blood anti-malarial drug concentrations ...
Chemoprophylactics are a vital tool in the fight against malaria. They can be used to protect popula...
The introduction of artemisinin-based combination therapy (ACT) substantially reduced malaria-relate...
Background: Artemisinin-based combination therapies (ACTs) are the mainstay of the current treatment...
A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment o...
A World Antimalarial Resistance Network (WARN) database has the potential to improve the treatment o...