Applications of Magnetic Particle Imaging to Brain Imaging

Magnetic Particle Imaging is a novel imaging modality with many applications in the preclinical, and soon, clinical space. In particular, MPIshows promise for imaging of various brain related pathologies, such as stroke, hemmorhage, and traumatic brain injury. In this thesis, wedemonstrate a series of first-in-animal proof-of-concept experiments that MPI could soon be superior to our conventional imaging technologies, including X-ray CT, MRI, ultrasounds and nuclear medicine for particular neuroimaging applications. In the process, we will develop algorithmic enhancements to the image reconstruction of MPI signals in order to achieve real time interventional imaging, much like X-ray fluoroscopic imaging, but without ionizing radiation and significant risksof catheter and iodinated contrast media