Add to ORKGAlthough DNA methylation is a key regulator of gene expression, the comprehensive methylation landscape of metastatic cancer has never been defined. Through whole-genome bisulfite sequencing paired with deep whole-genome and transcriptome sequencing of 100 castration-resistant prostate metastases, we discovered alterations affecting driver genes that were detectable only with integrated whole-genome approaches. Notably, we observed that 22% of tumors exhibited a novel epigenomic subtype associated with hypermethylation and somatic mutations in TET2, DNMT3B, IDH1 and BRAF. We also identified intergenic regions where methylation is associated with RNA expression of the oncogenic driver genes AR, MYC and ERG. Finally, we showed that differenti...
DNA methylation is an important contributor for prostate cancer development and progression. It has ...
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/...
Background Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countr...
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landsc...
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landsc...
A critical need in understanding the biology of prostate cancer is characterizing the molecular diff...
SummaryA critical need in understanding the biology of prostate cancer is characterizing the molecul...
Altered genome methylation is a hallmark of human malignancies. In this study, high-throughput analy...
Epigenetic modifications remain dynamic in most somatic cells to enable flexible gene activity. Simu...
Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations in epigen...
Although prostate cancer (PCa) is the second leading cause of cancer death among men worldwide, not ...
Prostate cancer (PCa) is the most common malignancy in men. Epigenetic alterations, including DNA me...
DNA methylation is one of the most important epigenetic mechanisms in regulating gene expression. Ge...
Abstract Background Current diagnostic tools for prostate cancer lack specificity and sensitivity fo...
Aberrant DNA methylation in gene promoters causes gene silencing and is a common event in prostate c...
DNA methylation is an important contributor for prostate cancer development and progression. It has ...
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/...
Background Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countr...
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landsc...
Although DNA methylation is a key regulator of gene expression, the comprehensive methylation landsc...
A critical need in understanding the biology of prostate cancer is characterizing the molecular diff...
SummaryA critical need in understanding the biology of prostate cancer is characterizing the molecul...
Altered genome methylation is a hallmark of human malignancies. In this study, high-throughput analy...
Epigenetic modifications remain dynamic in most somatic cells to enable flexible gene activity. Simu...
Human cancers almost ubiquitously harbor epigenetic alterations. Although such alterations in epigen...
Although prostate cancer (PCa) is the second leading cause of cancer death among men worldwide, not ...
Prostate cancer (PCa) is the most common malignancy in men. Epigenetic alterations, including DNA me...
DNA methylation is one of the most important epigenetic mechanisms in regulating gene expression. Ge...
Abstract Background Current diagnostic tools for prostate cancer lack specificity and sensitivity fo...
Aberrant DNA methylation in gene promoters causes gene silencing and is a common event in prostate c...
DNA methylation is an important contributor for prostate cancer development and progression. It has ...
RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/...
Background Prostate cancer (PCa) has the highest incidence rates of cancers in men in western countr...