Add to ORKGNew influenza vaccines that provide effective and broad protection are desperately needed. Live attenuated viruses are attractive vaccine candidates because they can elicit both humoral and cellular immune responses. However, recent formulations of live attenuated influenza vaccines (LAIVs) have not been protective. We combined high-coverage transposon mutagenesis of influenza virus with a rapid high-throughput screening for attenuation to generate W7-791, a live attenuated mutant virus strain. W7-791 produced only a transient asymptomatic infection in adult and neonatal mice even at doses 100-fold higher than the LD50 of the parent strain. A single administration of W7-791 conferred full protection to mice against lethal challenge with H1N...
Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically naïv...
Continued H5N1 virus infection in humans highlights the need for vaccine strategies that provide cro...
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics and pa...
New influenza vaccines that provide effective and broad protection are desperately needed. Live atte...
Although vaccines against influenza A virus are the most effective method to combat infection, it is...
Avian influenza viruses continue to cross the species barrier, and if such viruses become transmissi...
Currently, influenza vaccine manufacturers need to produce 1-5 x 107 PFU of each vaccine strain to f...
Live attenuated influenza vaccines (LAIVs) are promising tools for the induction of broad protection...
The development of an influenza vaccine with broad protection and durability remains an attractive i...
Avian influenza A (H7N9) virus has emerged recently and continues to cause severe disease with a hig...
Avian influenza A (H7N9) virus has emerged recently and continues to cause severe disease with a hig...
Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically na&i...
ABSTRACT New vaccine technologies are being investigated for their ability to elicit broadly cross-p...
AbstractThe appearance of human infections caused by avian influenza A H7 subtype viruses underscore...
Influenza A and B viruses cause significant morbidity and mortality worldwide. Current influenza vac...
Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically naïv...
Continued H5N1 virus infection in humans highlights the need for vaccine strategies that provide cro...
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics and pa...
New influenza vaccines that provide effective and broad protection are desperately needed. Live atte...
Although vaccines against influenza A virus are the most effective method to combat infection, it is...
Avian influenza viruses continue to cross the species barrier, and if such viruses become transmissi...
Currently, influenza vaccine manufacturers need to produce 1-5 x 107 PFU of each vaccine strain to f...
Live attenuated influenza vaccines (LAIVs) are promising tools for the induction of broad protection...
The development of an influenza vaccine with broad protection and durability remains an attractive i...
Avian influenza A (H7N9) virus has emerged recently and continues to cause severe disease with a hig...
Avian influenza A (H7N9) virus has emerged recently and continues to cause severe disease with a hig...
Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically na&i...
ABSTRACT New vaccine technologies are being investigated for their ability to elicit broadly cross-p...
AbstractThe appearance of human infections caused by avian influenza A H7 subtype viruses underscore...
Influenza A and B viruses cause significant morbidity and mortality worldwide. Current influenza vac...
Influenza H7N9 virus is a potentially pandemic subtype to which most people are immunologically naïv...
Continued H5N1 virus infection in humans highlights the need for vaccine strategies that provide cro...
Influenza A viruses (IAVs) present major public health threats from annual seasonal epidemics and pa...