Cortical spreading depolarizations (CSDs) are increasingly suspected to play an exacerbating role in a range of acute brain injuries, including stroke, possibly through their interactions with cortical blood flow. We use simultaneous wide-field imaging of neural activity and hemodynamics in Thy1-GCaMP6f mice to explore the neurovascular dynamics of CSDs during and following Rose Bengal-mediated photothrombosis. CSDs are observed in all mice as slow-moving waves of GCaMP fluorescence extending far beyond the photothrombotic area. Initial CSDs are accompanied by profound vasoconstriction and leave residual oligemia and ischemia in their wake. Later, CSDs evoke variable responses, from constriction to biphasic to vasodilation. However, CSD-evo...
Objectives: Cortical spreading depression (CSD), a propagating phenomenon of depolarizing neurons an...
Cortical spreading depolarization (CSD) is an emerging mode of secondary neuronal damage in acute br...
Background: Cortical spreading depolarization (CSD) is a massive neuro-glial depolarization wave,...
Summary: Cortical spreading depolarizations (CSDs) are increasingly suspected to play an exacerbatin...
A modern understanding of how cerebral cortical lesions develop after acute brain injury is based on...
The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related t...
The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related t...
The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related t...
How does infarction in victims of stroke and other types of acute brain injury expand to its definit...
Cortical spreading depression (CSD) involves mass depolarization of neurons and glial cells accompan...
International audienceBackground: Cortical spreading depolarization (CSD) is a massive neuro-glial d...
Regional cerebral blood flow (rCBF) is spatially and temporally adjusted to local energy needs. This...
ABSTRACT: A cortical spreading depolarization consists on a sudden, transient, generally lessive an...
Neurons and the underlying vascular structure that maintains the nutrients necessary for their norma...
Cortical spreading depression (CSD) is a pronounced depolarization of neurons and glia that spreads ...
Objectives: Cortical spreading depression (CSD), a propagating phenomenon of depolarizing neurons an...
Cortical spreading depolarization (CSD) is an emerging mode of secondary neuronal damage in acute br...
Background: Cortical spreading depolarization (CSD) is a massive neuro-glial depolarization wave,...
Summary: Cortical spreading depolarizations (CSDs) are increasingly suspected to play an exacerbatin...
A modern understanding of how cerebral cortical lesions develop after acute brain injury is based on...
The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related t...
The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related t...
The dynamic vascular responses during cortical spreading depolarization (CSD) are causally related t...
How does infarction in victims of stroke and other types of acute brain injury expand to its definit...
Cortical spreading depression (CSD) involves mass depolarization of neurons and glial cells accompan...
International audienceBackground: Cortical spreading depolarization (CSD) is a massive neuro-glial d...
Regional cerebral blood flow (rCBF) is spatially and temporally adjusted to local energy needs. This...
ABSTRACT: A cortical spreading depolarization consists on a sudden, transient, generally lessive an...
Neurons and the underlying vascular structure that maintains the nutrients necessary for their norma...
Cortical spreading depression (CSD) is a pronounced depolarization of neurons and glia that spreads ...
Objectives: Cortical spreading depression (CSD), a propagating phenomenon of depolarizing neurons an...
Cortical spreading depolarization (CSD) is an emerging mode of secondary neuronal damage in acute br...
Background: Cortical spreading depolarization (CSD) is a massive neuro-glial depolarization wave,...