Human genetics provides unbiased insights into the causes of human disease, which can be used to create a foundation for effective ways to more accurately diagnose patients, stratify patients for more successful clinical trials, discover and develop new therapies, and ultimately help patients choose the safest and most promising therapeutic option based on their risk profile. But the process for translating basic observations from human genetics studies into pathogenic disease mechanisms and treatments is laborious and complex, and this challenge has particularly slowed the development of interventions for neurodegenerative disease. In this review, we discuss the many steps in the process, the important considerations at each stage, and som...
Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of causal ge...
Neurodevelopmental disorders (NDDs) affect >4.7% of individuals world-wide. Most cases are expect...
During the past three decades, we have witnessed remarkable advances in our understanding of the mol...
Genetics has led to a new focus regarding approaches to the most prevalent diseases today. Ascertain...
Neurodegenerative and neuropsychiatric disorders are pervasive and debilitating conditions character...
The transcriptomic and proteomic techniques presented in part I (Functional Genomics meets neurodege...
Research on biomarkers and genetics shares a number of objectives, including the identification of n...
AbstractBrain disorders remain one of the defining challenges of modern medicine and among the most ...
Neurodegenerative, neurodevelopmental and neuropsychiatric disorders are among the greatest public h...
The integration of high-throughput genomics and neuroimaging technology has the promise of providing...
Brain disorders pose major challenges to medicine and treatment innovation. This is because their sp...
Brain disorders pose major challenges to medicine and treatment innovation. This is because their sp...
Despite the remarkable number of scientific breakthroughs of the last 100 years, the treatment of ne...
AbstractNeurological disorders comprise a variety of complex diseases in the central nervous system,...
Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of causal ge...
Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of causal ge...
Neurodevelopmental disorders (NDDs) affect >4.7% of individuals world-wide. Most cases are expect...
During the past three decades, we have witnessed remarkable advances in our understanding of the mol...
Genetics has led to a new focus regarding approaches to the most prevalent diseases today. Ascertain...
Neurodegenerative and neuropsychiatric disorders are pervasive and debilitating conditions character...
The transcriptomic and proteomic techniques presented in part I (Functional Genomics meets neurodege...
Research on biomarkers and genetics shares a number of objectives, including the identification of n...
AbstractBrain disorders remain one of the defining challenges of modern medicine and among the most ...
Neurodegenerative, neurodevelopmental and neuropsychiatric disorders are among the greatest public h...
The integration of high-throughput genomics and neuroimaging technology has the promise of providing...
Brain disorders pose major challenges to medicine and treatment innovation. This is because their sp...
Brain disorders pose major challenges to medicine and treatment innovation. This is because their sp...
Despite the remarkable number of scientific breakthroughs of the last 100 years, the treatment of ne...
AbstractNeurological disorders comprise a variety of complex diseases in the central nervous system,...
Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of causal ge...
Most neuropsychiatric disorders are highly polygenic, implicating hundreds to thousands of causal ge...
Neurodevelopmental disorders (NDDs) affect >4.7% of individuals world-wide. Most cases are expect...
During the past three decades, we have witnessed remarkable advances in our understanding of the mol...