Add to ORKGThe role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorphic effects in some biological studies. Here, we used high-throughput phenotype data from 14,250 wildtype and 40,192 mutant mice (representing 2,186 knockout lines), analysed for up to 234 traits, and found a large proportion of mammalian traits both in wildtype and mutants are influenced by sex. This result has implications for interpreting disease phenotypes in animal models and humans
The impact of two mouse models is reviewed, the Four Core Genotypes and XY* models. The models are u...
<p>The vertical axis is the percent of variation explained. The ten largest effects are labeled.</p
Mice are important models for biomedical research by providing the possibility of standardizing gen...
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorp...
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorp...
<div><p>The extent to which sex-specific genetic effects contribute to phenotypic variation is large...
This is the final version. Available from Wiley via the DOI in this record. No new data were collect...
A sophisticated mechanistic understanding of physiology and disease requires knowledge of how sex-bi...
Breeding records for 15 of the 42 C57BL/10SnJ Congenic Histocompatibility Mouse Strains from the Spe...
Supporting material for the manuscript “Prevalence of sexual dimorphism in mammalian phenotypic trai...
Differences in clinical phenotypes between the sexes are well documented and have their roots in dif...
Sex differences in the lifetime risk and expression of disease are well-known. Preclinical research ...
Linkage analysis and genome-wide association studies have discovered a vast number of associations b...
All therian mammals have a similar XY/XX sex determination system except for a dozen species. The Af...
International audienceDifferences in biological performance, at both intra- and inter-specific level...
The impact of two mouse models is reviewed, the Four Core Genotypes and XY* models. The models are u...
<p>The vertical axis is the percent of variation explained. The ten largest effects are labeled.</p
Mice are important models for biomedical research by providing the possibility of standardizing gen...
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorp...
The role of sex in biomedical studies has often been overlooked, despite evidence of sexually dimorp...
<div><p>The extent to which sex-specific genetic effects contribute to phenotypic variation is large...
This is the final version. Available from Wiley via the DOI in this record. No new data were collect...
A sophisticated mechanistic understanding of physiology and disease requires knowledge of how sex-bi...
Breeding records for 15 of the 42 C57BL/10SnJ Congenic Histocompatibility Mouse Strains from the Spe...
Supporting material for the manuscript “Prevalence of sexual dimorphism in mammalian phenotypic trai...
Differences in clinical phenotypes between the sexes are well documented and have their roots in dif...
Sex differences in the lifetime risk and expression of disease are well-known. Preclinical research ...
Linkage analysis and genome-wide association studies have discovered a vast number of associations b...
All therian mammals have a similar XY/XX sex determination system except for a dozen species. The Af...
International audienceDifferences in biological performance, at both intra- and inter-specific level...
The impact of two mouse models is reviewed, the Four Core Genotypes and XY* models. The models are u...
<p>The vertical axis is the percent of variation explained. The ten largest effects are labeled.</p
Mice are important models for biomedical research by providing the possibility of standardizing gen...