Add to ORKGThe characterization of cancer genomes has provided insight into somatically altered genes across tumors, transformed our understanding of cancer biology, and enabled tailoring of therapeutic strategies. However, the function of most cancer alleles remains mysterious, and many cancer features transcend their genomes. Consequently, tumor genomic characterization does not influence therapy for most patients. Approaches to understand the function and circuitry of cancer genes provide complementary approaches to elucidate both oncogene and non-oncogene dependencies. Emerging work indicates that the diversity of therapeutic targets engendered by non-oncogene dependencies is much larger than the list of recurrently mutated genes. Here we describe...
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature ...
Systematic studies of the cancer genome have exploded in recent years. These studies have revealed s...
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature ...
The characterization of cancer genomes has provided insight into somatically altered genes across tu...
The analysis of human cancer by genome sequencing and various types of arrays has proved that many t...
The identification of good targets is a critical step for the development of targeted therapies for ...
Over the last decade we have witnessed the convergence of two powerful experimental designs toward a...
Abstract: New molecular insight reveals novel points of attack for targeted cancer therapy. The rece...
Summary Systematic studies of cancer genomes have provided unprecedented insights into the molecular...
SummaryLarge efforts dedicated to detect somatic alterations across tumor genomes/exomes are expecte...
The genomes of all cancers accumulate somatic mutations. These include nucleotide substitutions, sma...
Tumors are composed of an evolving population of cells subjected to tissue-specific selection, which...
Abstract It is increasingly clear that complex networks of relationships between genes and/or protei...
Further advances in the prevention, diagnosis and treatment of cancer requires a more complete knowl...
SummarySystematic studies of cancer genomes have provided unprecedented insights into the molecular ...
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature ...
Systematic studies of the cancer genome have exploded in recent years. These studies have revealed s...
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature ...
The characterization of cancer genomes has provided insight into somatically altered genes across tu...
The analysis of human cancer by genome sequencing and various types of arrays has proved that many t...
The identification of good targets is a critical step for the development of targeted therapies for ...
Over the last decade we have witnessed the convergence of two powerful experimental designs toward a...
Abstract: New molecular insight reveals novel points of attack for targeted cancer therapy. The rece...
Summary Systematic studies of cancer genomes have provided unprecedented insights into the molecular...
SummaryLarge efforts dedicated to detect somatic alterations across tumor genomes/exomes are expecte...
The genomes of all cancers accumulate somatic mutations. These include nucleotide substitutions, sma...
Tumors are composed of an evolving population of cells subjected to tissue-specific selection, which...
Abstract It is increasingly clear that complex networks of relationships between genes and/or protei...
Further advances in the prevention, diagnosis and treatment of cancer requires a more complete knowl...
SummarySystematic studies of cancer genomes have provided unprecedented insights into the molecular ...
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature ...
Systematic studies of the cancer genome have exploded in recent years. These studies have revealed s...
Systematic studies of cancer genomes have provided unprecedented insights into the molecular nature ...