Previous studies have shown that gut-microbiome is associated with nonalcoholic fatty liver disease (NAFLD). We aimed to examine if serum metabolites, especially those derived from the gut-microbiome, have a shared gene-effect with hepatic steatosis and fibrosis. This is a cross-sectional analysis of a prospective discovery cohort including 156 well-characterized twins and families with untargeted metabolome profiling assessment. Hepatic steatosis was assessed using magnetic-resonance-imaging proton-density-fat-fraction (MRI-PDFF) and fibrosis using MR-elastography (MRE). A twin additive genetics and unique environment effects (AE) model was used to estimate the shared gene-effect between metabolites and hepatic steatosis and fibrosis. The ...
Rationale: Obesity could lead to several metabolic alterations, including non-alcoholic fatty liver ...
Studies have shown that hepatic steatosis and fibrosis are heritable and have a shared gene\ effect ...
BackgroundPrevious observational studies have indicated that an imbalance in gut microbiota may cont...
Previous studies have shown that gut-microbiome is associated with nonalcoholic fatty liver disease ...
International audiencePrevious studies have shown that gut-microbiome is associated with nonalcoholi...
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of non...
Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes mellitus, two m...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and ...
BACKGROUND & AIMS: The intestinal microbiome might affect the development and severity of nonalcohol...
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in western c...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease,...
Aim: The microbiome has been shown to be pivotal in the development of metabolic associated fatty li...
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract...
The presence of advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is the most important ...
BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver dis...
Rationale: Obesity could lead to several metabolic alterations, including non-alcoholic fatty liver ...
Studies have shown that hepatic steatosis and fibrosis are heritable and have a shared gene\ effect ...
BackgroundPrevious observational studies have indicated that an imbalance in gut microbiota may cont...
Previous studies have shown that gut-microbiome is associated with nonalcoholic fatty liver disease ...
International audiencePrevious studies have shown that gut-microbiome is associated with nonalcoholi...
A growing body of evidence suggests interplay between the gut microbiota and the pathogenesis of non...
Gut microbiota dysbiosis has been repeatedly observed in obesity and type 2 diabetes mellitus, two m...
Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver disease in the world, and ...
BACKGROUND & AIMS: The intestinal microbiome might affect the development and severity of nonalcohol...
Non-alcoholic fatty liver disease (NAFLD) is the leading cause of chronic liver disease in western c...
Non-alcoholic fatty liver disease (NAFLD) is one of the most common causes of chronic liver disease,...
Aim: The microbiome has been shown to be pivotal in the development of metabolic associated fatty li...
The gut microbiome, the multispecies community of microbes that exists in the gastrointestinal tract...
The presence of advanced fibrosis in nonalcoholic fatty liver disease (NAFLD) is the most important ...
BackgroundNon-alcoholic fatty liver disease (NAFLD) is the most prevalent cause of chronic liver dis...
Rationale: Obesity could lead to several metabolic alterations, including non-alcoholic fatty liver ...
Studies have shown that hepatic steatosis and fibrosis are heritable and have a shared gene\ effect ...
BackgroundPrevious observational studies have indicated that an imbalance in gut microbiota may cont...