Genomic and phenotypic insights from an atlas of genetic effects on DNA methylation
- MIN, Josine L.
- HEMANI, Gibran
- HANNON, Eilis
- DEKKERS, Koen F.
- CASTILLO-FERNANDEZ, Juan
- LUIJK, Rene
- CARNERO-MONTORO, Elena
- LAWSON, Daniel J.
- BURROWS, Kimberley
- SUDERMAN, Matthew
- BRETHERICK, Andrew D.
- RICHARDSON, Tom G.
- KLUGHAMMER, Johanna
- IOTCHKOVA, Valentina
- SHARP, Gemma
- AL KHLEIFAT, Ahmad
- SHATUNOV, Aleksey
- IACOANGELI, Alfredo
- MCARDLE, Wendy L.
- HO, Karen M.
- KUMAR, Ashish
- SODERHALL, Cilla
- SORIANO-TARRAGA, Carolina
- GIRALT-STEINHAUER, Eva
- KAZMI, Nabila
- MASON, Dan
- MCRAE, Allan F.
- CORCORAN, David L.
- SUGDEN, Karen
- KASELA, Silva
- CARDONA, Alexia
- DAY, Felix R.
- CUGLIARI, Giovanni
- VIBERTI, Clara
- GUARRERA, Simonetta
- LERRO, Michael
- GUPTA, Richa
- BOLLEPALLI, Sailalitha
- MANDAVIYA, Pooja
- ZENG, Yanni
- CLARKE, Toni Kim
- WALKER, Rosie M.
- SCHMOLL, Vanessa
- CZAMARA, Darina
- RUIZ-ARENAS, Carlos
- REZWAN, Faisal I.
- MARIONI, Riccardo E.
- LIN, Tian
- AWALOFF, Yvonne
- GERMAIN, Marine
- AISSI, Dylan
- ZWAMBORN, Ramona
- VAN EIJK, Kristel
- DEKKER, Annelot
- VAN DONGEN, Jenny
- HOTTENGA, Jouke Jan
- WILLEMSEN, Gonneke
- XU, Cheng Jian
- BARTUREN, Guillermo
- CATALA-MOLL, Francesc
- KERICK, Martin
- WANG, Carol
- MELTON, Phillip
- ELLIOTT, Hannah R.
- SHIN, Jean
- BERNARD, Manon
- YET, Idil
- SMART, Melissa
- GORRIE-STONE, Tyler
- CONSORTIUM, Bios
- SHAW, Chris
- AL CHALABI, Ammar
- RING, Susan M.
- PERSHAGEN, Goran
- MELEN, Erik
- JIMENEZ-CONDE, Jordi
- ROQUER, Jaume
- LAWLOR, Deborah A.
- WRIGHT, John
- MARTIN, Nicholas G.
- MONTGOMERY, Grant W.
- MOFFITT, Terrie E.
- POULTON, Richie
- ESKO, Tonu
- MILANI, Lili
- METSPALU, Andres
- PERRY, John R. B.
- ONG, Ken K.
- WAREHAM, Nicholas J.
- MATULLO, Giuseppe
- SACERDOTE, Carlotta
- PANICO, Salvatore
- CASPI, Avshalom
- ARSENEAULT, Louise
- GAGNON, France
- OLLIKAINEN, Miina
- KAPRIO, Jaakko
- FELIX, Janine F.
- RIVADENEIRA, Fernando
- TIEMEIER, Henning
- VAN IJZENDOORN, Marinus H.
- UITTERLINDEN, Andre G.
- JADDOE, Vincent W. V.
- HALEY, Chris
- MCINTOSH, Andrew M.
- EVANS, Kathryn L.
- MURRAY, Alison
- RAIKKONEN, Katri
- LAHTI, Jari
- NOHR, Ellen A.
- SORENSEN, Thorkild I. A.
- HANSEN, Torben
- MORGEN, Camilla S.
- BINDER, Elisabeth B.
- LUCAE, Susanne
- GONZALEZ, Juan Ramon
- BUSTAMANTE, Mariona
- SUNYER, Jordi
- HOLLOWAY, John W.
- KARMAUS, Wilfried
- ZHANG, Hongmei
- DEARY, Ian J.
- WRAY, Naomi R.
- STARR, John M.
- BEEKMAN, Marian
- VAN HEEMST, Diana
- SLAGBOOM, P. Eline
- MORANGE, Pierre Emmanuel
- TREGOUET, David-Alexandre
- VELDINK, Jan H.
- DAVIES, Gareth E.
- DE GEUS, Eco J. C.
- BOOMSMA, Dorret I.
- VONK, Judith M.
- BRUNEKREEF, Bert
- KOPPELMAN, Gerard H.
- ALARCON-RIQUELME, Marta E.
- HUANG, Rae Chi
- PENNELL, Craig E.
- VAN MEURS, Joyce
- IKRAM, M. Arfan
- HUGHES, Alun D.
- TILLIN, Therese
- CHATURVEDI, Nish
- PAUSOVA, Zdenka
- PAUS, Tomas
- SPECTOR, Timothy D.
- KUMARI, Meena
- SCHALKWYK, Leonard C.
- VISSCHER, Peter M.
- DAVEY SMITH, George
- BOCK, Christoph
- GAUNT, Tom R.
- BELL, Jordana T.
- HEIJMANS, Bastiaan T.
- MILL, Jonathan
- RELTON, Caroline L.
DOIAbstract
Characterizing genetic influences on DNA methylation (DNAm) provides an opportunity to understand mechanisms underpinning gene regulation and disease. In the present study, we describe results of DNAm quantitative trait locus (mQTL) analyses on 32,851 participants, identifying genetic variants associated with DNAm at 420,509 DNAm sites in blood. We present a database of >270,000 independent mQTLs, of which 8.5% comprise long-range (trans) associations. Identified mQTL associations explain 15-17% of the additive genetic variance of DNAm. We show that the genetic architecture of DNAm levels is highly polygenic. Using shared genetic control between distal DNAm sites, we constructed networks, identifying 405 discrete genomic communities enriche...
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