Objective: Measure total tau levels in the circulation of living humans, validate the methods employed and determine if there are consistent differences in total tau levels between normal controls and individuals with mild cognitive impairment (MCI) and/or Alzheimer\u27s disease (AD). Methods: Employing ELISA methods, validated by Western bolts using three separate tau antibodies, we quantified total tau levels in serially collected serum and plasma samples from individuals longitudinally evaluated for cognitive performance. Results: We identified substantial levels of tau in human circulation using plasma, but not serum. The measurement of authentic tau protein was verified by Western blots using a C-terminal specific antibody, an N-termin...
Objective: There is an urgent need for sensitive, widely available, blood-based screening tests to i...
Objective: Amyloid 1-42 (Aβ42) and tau in cerebrospinal fluid are currently used as markers for diag...
Objective: To evaluate CSF levels of beta-amyloid((1-42)) (A beta(42)) alone and in combination with...
INTRODUCTION: The tau protein plays a central role in Alzheimer's disease (AD), and there is huge in...
Objective: Alzheimer’s disease (AD) is a devastating neurological disease characterized by pathologi...
Objective: To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related...
Truncated tau appears to be specifically related to disease pathology and recent studies have shown ...
The close correlation between Tau pathology and Alzheimer's disease (AD) progression makes this prot...
The utility of plasma amyloid beta (Aβ) and tau levels for the clinical diagnosis of Alzheimer\u27s ...
<div><p>Background</p><p>Truncated tau appears to be specifically related to disease pathology and r...
OBJECTIVE: To investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can disting...
The elevated level of cerebrospinal fluid (CSF) Tau and phosphorylated Tau181 (p-Tau181) proteins ar...
Previous studies have demonstrated increased tau plasma levels in patients with Alzheimer's disease ...
Objective To investigate whether p-tau T217 assay in cerebrospinal fluid (CSF) can distinguishes Al...
Abstract Background Tau vaccination and administration of anti-tau antibodies can prevent pathology ...
Objective: There is an urgent need for sensitive, widely available, blood-based screening tests to i...
Objective: Amyloid 1-42 (Aβ42) and tau in cerebrospinal fluid are currently used as markers for diag...
Objective: To evaluate CSF levels of beta-amyloid((1-42)) (A beta(42)) alone and in combination with...
INTRODUCTION: The tau protein plays a central role in Alzheimer's disease (AD), and there is huge in...
Objective: Alzheimer’s disease (AD) is a devastating neurological disease characterized by pathologi...
Objective: To test whether plasma tau is altered in Alzheimer disease (AD) and whether it is related...
Truncated tau appears to be specifically related to disease pathology and recent studies have shown ...
The close correlation between Tau pathology and Alzheimer's disease (AD) progression makes this prot...
The utility of plasma amyloid beta (Aβ) and tau levels for the clinical diagnosis of Alzheimer\u27s ...
<div><p>Background</p><p>Truncated tau appears to be specifically related to disease pathology and r...
OBJECTIVE: To investigate whether tau phosphorylated at Thr217 (p-tau T217) assay in CSF can disting...
The elevated level of cerebrospinal fluid (CSF) Tau and phosphorylated Tau181 (p-Tau181) proteins ar...
Previous studies have demonstrated increased tau plasma levels in patients with Alzheimer's disease ...
Objective To investigate whether p-tau T217 assay in cerebrospinal fluid (CSF) can distinguishes Al...
Abstract Background Tau vaccination and administration of anti-tau antibodies can prevent pathology ...
Objective: There is an urgent need for sensitive, widely available, blood-based screening tests to i...
Objective: Amyloid 1-42 (Aβ42) and tau in cerebrospinal fluid are currently used as markers for diag...
Objective: To evaluate CSF levels of beta-amyloid((1-42)) (A beta(42)) alone and in combination with...