Phosphorus and calcium imbalances in diabetic nephropathy

Department of Endocrinology, USMF Nicolae Testimițanu", Chișinău, Republic of MoldovaIntroduction: It was performed a clinical study on phosphorus and calcium imbalances in diabetic nephropathy. Diabetic nephropathy is a pathology that affects the renal function. Phosphocalcic metabolism is closely related to this process. Disorders include the increase of serum phosphorus level and decrease of the serum calcium level. Disorders in mineral and bone metabolism in diabetic nephropathy are associated with high morbidity and mortality. Purpose and objectives: To study clinical and paraclinical indicators and identify the metabolic changes of calcium and phosphorus according to glomerular filtration rate (GFR) in diabetic nephropathy. Materials and Methods: Case histories of patients treated in the Department of Endocrinology of the SCR during 2012-2014. We have evaluated 360 clinical review charts, 91 of them were selected for this clinical study. The study results were obtained by statistical processing, with analysis of statistical veracity indices. Results: We found a direct correlation between GFR and serum calcium level and an inverse correlation between GFR and duration of diabetes, diastolic blood pressure, serum phosphorus, cholesterol, triglycerides, LDL and creatinine in study groups. Conclusions: (1) With the decline of GFR there is a decrease of the serum concentration of calcium. (2) With decrease of GFR in diabetic nephropathy the serum concentration of phosphorus increase