Purpose: Delivery of Advanced Therapy Medicinal Products to the submacular space is increasingly evolving into a therapeutic modality. Cell replacement for age-related macular degeneration (AMD) and gene therapy for RPE65 are recent successful examples. Herein, a nonhuman primate (NHP) model was used to investigate surgical means to detach the macula. Methods: Sixteen eyes of 13 healthy macaques underwent a 25-gauge vitrectomy and subretinal injection of balanced salt solution monitored by microscope-integrated intra-operative optical coherence tomography (miOCT). The animals were followed with OCT and histology. Results: The miOCT monitoring allowed a more precise definition of surgical trauma ranging from an initial full-thickness foveal ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
PurposeTo investigate the influence of subretinal injection pressure on the microstructure of the re...
PurposeTo investigate the influence of subretinal injection pressure on the microstructure of the re...
Purpose: Subretinal injections (SRis) are commonly used in retinal gene therapy procedures to delive...
PURPOSE:To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovo...
PURPOSE:To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovo...
Background: Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell re...
Background: Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell re...
Purpose: To describe the “crocodile technique”, a new ophthalmic surgery technique for removing subr...
Purpose: To describe the “crocodile technique”, a new ophthalmic surgery technique for removing subr...
PURPOSE: To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photov...
PURPOSE: Our objective was to examine the feasibility of rotating choriocapillaris, Bruch's membrane...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
PurposeTo investigate the influence of subretinal injection pressure on the microstructure of the re...
PurposeTo investigate the influence of subretinal injection pressure on the microstructure of the re...
Purpose: Subretinal injections (SRis) are commonly used in retinal gene therapy procedures to delive...
PURPOSE:To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovo...
PURPOSE:To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photovo...
Background: Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell re...
Background: Human pluripotent stem cells (hPSCs) provide a promising cell source for retinal cell re...
Purpose: To describe the “crocodile technique”, a new ophthalmic surgery technique for removing subr...
Purpose: To describe the “crocodile technique”, a new ophthalmic surgery technique for removing subr...
PURPOSE: To evaluate the surgical technique for subretinal implantation of two sizes of PRIMA photov...
PURPOSE: Our objective was to examine the feasibility of rotating choriocapillaris, Bruch's membrane...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...
International audiencePURPOSE:To evaluate the surgical technique for subretinal implantation of two ...