Genome-wide association study of circulating interleukin 6 levels identifies novel loci
- CHARGE Inflammation Working Group
- Ahluwalia, Tarunveer S.
- Prins, Bram P.
- Abdollahi, Mohammadreza
- Armstrong, Nicola J.
- Aslibekyan, Stella
- Bain, Lisa
- Jefferis, Barbara
- Baumert, Jens
- Beekman, Marian
- Ben-Shlomo, Yoav
- Bis, Joshua C.
- Mitchell, Braxton D.
- de Geus, Eco
- Delgado, Graciela E.
- Marek, Diana
- Eriksson, Joel
- Kajantie, Eero
- Kanoni, Stavroula
- Kemp, John P.
- Lu, Chen
- Marioni, Riccardo E.
- McLachlan, Stela
- Milaneschi, Yuri
- Nolte, Ilja M.
- Petrelis, Alexandros M.
- Porcu, Eleonora
- Sabater-Lleal, Maria
- Naderi, Elnaz
- Seppälä, Ilkka
- Shah, Tina
- Singhal, Gaurav
- Standl, Marie
- Teumer, Alexander
- Thalamuthu, Anbupalam
- Thiering, Elisabeth
- Trompet, Stella
- Ballantyne, Christie M.
- Benjamin, Emelia J.
- Casas, Juan P.
- Toben, Catherine
- Dedoussis, George
- Deelen, Joris
- Durda, Peter
- Engmann, Jorgen
- Feitosa, Mary F.
- Grallert, Harald
- Hammarstedt, Ann
- Lahti, Jari
- Eriksson, Johan G.
- Lehtimäki, Terho
DOIAbstract
Interleukin 6 (IL-6) is a multifunctional cytokine with both pro- and anti-inflammatory properties with a heritability estimate of up to 61%. The circulating levels of IL-6 in blood have been associated with an increased risk of complex disease pathogenesis. We conducted a two-staged, discovery and replication meta genome-wide association study (GWAS) of circulating serum IL-6 levels comprising up to 67 428 (ndiscovery = 52 654 and nreplication = 14 774) individuals of European ancestry. The inverse variance fixed effects based discovery meta-analysis, followed by replication led to the identification of two independent loci, IL1F10/IL1RN rs6734238 on chromosome (Chr) 2q14, (Pcombined = 1.8 × 10-11), HLA-DRB1/DRB5 rs660895 on Chr6p21 (Pcomb...
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