6-Aminouracil and 2-bromoethyl amine were prepared, as starting materials to be introduced as an alkylating reagent with sodium carbonate as a catalyst. Acyclic nucleoside was prepared for the first time, the expected structure of the final new compound 3 was determined based on IR, NMR, and mass spectroscopy, with safe and mild reaction conditions. The synthesized acyclic nucleoside has a potent and efficient antimicrobial activity compared to reference drugs particularly as an antibacterial agent, and can be used as an alternative to the commonly used antibiotics after performing the necessary biological research for its validation
The synthesis of novel nucleoside and nucleotide analogues in which the sugar moiety is replaced by ...
A series of novel acyclic oxonucleoside, 2',3'-dideoxy-4'-thio- and 4'-thio-L-nucleoside analogues h...
Les analogues synthétiques des nucléosides naturels constituant des acides nucléiques occupent une p...
Acyclic nucleosides have been of considerable interest since the approval of aciclovir by the FDA to...
Acyclic nucleosides have been of considerable interest since the approval of aciclovir by the FDA to...
Nucleoside derivatives are important therapeutic drugs and are the focal point in the ongoing search...
Double headed acyclo-C-nucleosides, 1,4-bis(3-mercapto-1H-1,2,4-triazol-5-yl)butane-1,2,3,4-tetrol (...
AbstractDouble headed acyclo-C-nucleosides, 1,4-bis(3-mercapto-1H-1,2,4-triazol-5-yl)butane-1,2,3,4-...
Reaction of the quinolone carboxylic acids 1 and 2 with (2-acetoxyethoxy)methyl chloride 3 in the pr...
Our goal in this research, some new nucleoside analogues was synthesized. Starting from ?-D glucose ...
Acyclic, achiral nucleoside derivatives 1b-e of adenine, cytosine, 5-methylcytosine, and guanine, co...
A very short and concise synthetic route for a novel acyclic version of d4T is described. The requir...
Nucleosides and their analogues are an important, well-established class of clinically useful medici...
5-Phosphate triesters were derived from the nucleosides 882C (1), acyclovir (2), 5'-hydroxyethoxymet...
Boesen Thomas ; Pedersen Daniel Sejer ; Jensen Jacob ; Munck Michael T. ; Nielsen Brian M. ; Peterse...
The synthesis of novel nucleoside and nucleotide analogues in which the sugar moiety is replaced by ...
A series of novel acyclic oxonucleoside, 2',3'-dideoxy-4'-thio- and 4'-thio-L-nucleoside analogues h...
Les analogues synthétiques des nucléosides naturels constituant des acides nucléiques occupent une p...
Acyclic nucleosides have been of considerable interest since the approval of aciclovir by the FDA to...
Acyclic nucleosides have been of considerable interest since the approval of aciclovir by the FDA to...
Nucleoside derivatives are important therapeutic drugs and are the focal point in the ongoing search...
Double headed acyclo-C-nucleosides, 1,4-bis(3-mercapto-1H-1,2,4-triazol-5-yl)butane-1,2,3,4-tetrol (...
AbstractDouble headed acyclo-C-nucleosides, 1,4-bis(3-mercapto-1H-1,2,4-triazol-5-yl)butane-1,2,3,4-...
Reaction of the quinolone carboxylic acids 1 and 2 with (2-acetoxyethoxy)methyl chloride 3 in the pr...
Our goal in this research, some new nucleoside analogues was synthesized. Starting from ?-D glucose ...
Acyclic, achiral nucleoside derivatives 1b-e of adenine, cytosine, 5-methylcytosine, and guanine, co...
A very short and concise synthetic route for a novel acyclic version of d4T is described. The requir...
Nucleosides and their analogues are an important, well-established class of clinically useful medici...
5-Phosphate triesters were derived from the nucleosides 882C (1), acyclovir (2), 5'-hydroxyethoxymet...
Boesen Thomas ; Pedersen Daniel Sejer ; Jensen Jacob ; Munck Michael T. ; Nielsen Brian M. ; Peterse...
The synthesis of novel nucleoside and nucleotide analogues in which the sugar moiety is replaced by ...
A series of novel acyclic oxonucleoside, 2',3'-dideoxy-4'-thio- and 4'-thio-L-nucleoside analogues h...
Les analogues synthétiques des nucléosides naturels constituant des acides nucléiques occupent une p...