Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation

CITATION: Mabank, T., et al. 2019. Synthesis of 2-substituted tetrahydroisoquinolin-6-ols: potential scaffolds for estrogen receptor modulation and / or microtubule degradation. ARKIVOC, iv:245-279, doi:10.24820/ark.5550190.p010.962.The original publication is available at https://www.arkat-usa.org/arkivoc-journalENGLISH ABSTRACT: 6-Methoxytetrahydroisoquinoline hydrochloride was converted into four small libraries of substituted ureas, thioureas, sulfonamides and N-aryls, using the tetrahydroisoquinoline nitrogen as the scaffold-linking atom. Some of the compounds were evaluated for their ability to inhibit cell proliferation using the MCF7 (invasive ductal carcinoma) cell line.https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/2019/4/Publisher's versio