Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

Mouse CD8 alpha(+) DCs and human BDCA3(+) DCs are major producers of IFN-lambda in response to poly IC

Lauterbach, H
Bathke, B
Gilles, S
Traidl-Hoffmann, C
Luber, CA
Fejer, G
Freudenberg, MA
Davey, GM
Vremec, D
Kallies, A
Wu, L
Shortman, K
Chaplin, P
Suter, M
O'Keeffe, M
Hochrein, H

November 2010

Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. ...

Helper effector function of human T cells stimulated by anti-CD3 mAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction

Kwekkeboom, Jaap
De Rijk, Diana
De Groot, Cornelis
De Boer, Mark
Kasran, Ahmad
Barcy, Serge

March 1994

In this study we have investigated whether anti-CD3-induced human T cell help for immunoglobulin pro...

CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells.

Macal, M.
Tam, M.A.
Hesser, C.
Di Domizio, J.
Leger, P.
Gilliet, M.
Zuniga, E.I.

January 2016

Type I IFNs (IFN-I) are key innate mediators that create a profound antiviral state and orchestrate ...

Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

Haack, Stephanie
Baiker, Sarah
Schlegel, Jan
Sauer, Markus
Sparwasser, Tim
Langenhorst, Daniela
Beyersdorf, Niklas

January 2021

Like human Th1 cells, mouse Th1 cells also secrete IFN‐γ upon stimulation with a superagonistic anti...

Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.

Zoe Waibler
Linda Y Sender
Camilla Merten
Roland Hartig
Stefanie Kliche
Matthias Gunzer
Peter Reichardt
Ulrich Kalinke
Burkhart Schraven

Superagonistic CD28 antibodies (CD28SAs) activate T lymphocytes without concomitant perturbation of ...

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo.

Langenhorst, Daniela
Haack, Stephanie
Göb, Selina
Uri, Anna
Lühder, Fred
Vanhove, Bernard
Hünig, Thomas
Beyersdorf, Niklas

January 2018

International audienceCompared to naive T cells, differentiated T cells are thought to be less depen...

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo

Daniela Langenhorst
Stephanie Haack
Selina Göb
Anna Uri
Fred Lühder
Bernard Vanhove
Bernard Vanhove
Bernard Vanhove
Thomas Hünig
Niklas Beyersdorf

May 2018

Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimula...

In vitro MAP27 treatment promoted the production of IFN-γ in splenocytes from MAP27-immunized mice.

Xiang-Yu Wang (790019)
Zhao-Xia Huang (790020)
Yi-Guo Chen (593833)
Xiao Lu (355468)
Ping Zhu (11521)
Kun Wen (790021)
Ning Fu (68329)
Bei-Yi Liu (790022)

August 2015

Five days after the last boost immunization, splenocytes isolated from the mice (n = 5 mice per g...

CD28 costimulation of T helper 1 cells enhances cytokine release in vivo

Langenhorst, Daniela
Haack, Stephanie
Göb, Selina
Uri, Anna
Lühder, Fred
Vanhove, Bernhard
Hünig, Thomas
Beyersdorf, Niklas

January 2018

Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimula...

Ein neues Mausmodell zur Untersuchung der Zytokinfreisetzung nach Behandlung mit einem superagonistischen anti-CD28 Antikörper

Haack, Stephanie

January 2021

The adaptive immune system is known to provide highly specific and effective immunity against a broa...

IFN-γ signaling regulates the expansion of memory CD8+ T cells.

Yoshiko Iwai (49013)
Hiroaki Hemmi (49014)
Olga Mizenina (49015)
Shoko Kuroda (49016)
Koji Suda (49017)
Ralph M. Steinman (49018)

February 2013

(A, B) IL-18 production from DCs. (A) DCs isolated from spleen of IFN-γR1−/− and wild ...

CD43 is a murine T cell costimulatory receptor that functions independently of CD28.

Sperling, AI
Green, JM
Mosley, RL
Smith, PL
DiPaolo, RJ
Klein, JR
Bluestone, JA
Thompson, CB

July 1995

Costimulation mediated by the CD28 receptor has been shown to play an important role in the developm...

Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.

Tea Gogishvili
Daniela Langenhorst
Fred Lühder
Fernando Elias
Karin Elflein
Kevin M Dennehy
Ralf Gold
Thomas Hünig

Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regul...

Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice

Tea Gogishvili
Daniela Langenhorst
O Elias
Karin Elflein
Kevin M
Ralf Gold

January 2009

Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regul...

CD28 signaling increases CD226 expression and IL-3 secretion in CD4 T cells.

Manish J. Butte (154492)
Sun Jung Lee (154496)
Jonathan Jesneck (154500)
Mary E. Keir (154503)
W. Nicholas Haining (154505)
Arlene H. Sharpe (154508)

June 2012

Sorted naïve CD4+CD25- T cells from C57BL/6 wild type mice were stimulated with bead-bound anti-C...

Mouse CD8 alpha(+) DCs and human BDCA3(+) DCs are major producers of IFN-lambda in response to poly IC

Lauterbach, H
Bathke, B
Gilles, S
Traidl-Hoffmann, C
Luber, CA
Fejer, G
Freudenberg, MA
Davey, GM
Vremec, D
Kallies, A
Wu, L
Shortman, K
Chaplin, P
Suter, M
O'Keeffe, M
Hochrein, H

November 2010

Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. ...

Helper effector function of human T cells stimulated by anti-CD3 mAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction

Kwekkeboom, Jaap
De Rijk, Diana
De Groot, Cornelis
De Boer, Mark
Kasran, Ahmad
Barcy, Serge

March 1994

In this study we have investigated whether anti-CD3-induced human T cell help for immunoglobulin pro...

CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells.

Macal, M.
Tam, M.A.
Hesser, C.
Di Domizio, J.
Leger, P.
Gilliet, M.
Zuniga, E.I.

January 2016

Type I IFNs (IFN-I) are key innate mediators that create a profound antiviral state and orchestrate ...

Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

Haack, Stephanie
Baiker, Sarah
Schlegel, Jan
Sauer, Markus
Sparwasser, Tim
Langenhorst, Daniela
Beyersdorf, Niklas

January 2021

Like human Th1 cells, mouse Th1 cells also secrete IFN‐γ upon stimulation with a superagonistic anti...

Signaling signatures and functional properties of anti-human CD28 superagonistic antibodies.

Zoe Waibler
Linda Y Sender
Camilla Merten
Roland Hartig
Stefanie Kliche
Matthias Gunzer
Peter Reichardt
Ulrich Kalinke
Burkhart Schraven

Superagonistic CD28 antibodies (CD28SAs) activate T lymphocytes without concomitant perturbation of ...

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo.

Langenhorst, Daniela
Haack, Stephanie
Göb, Selina
Uri, Anna
Lühder, Fred
Vanhove, Bernard
Hünig, Thomas
Beyersdorf, Niklas

January 2018

International audienceCompared to naive T cells, differentiated T cells are thought to be less depen...

CD28 Costimulation of T Helper 1 Cells Enhances Cytokine Release In Vivo

Daniela Langenhorst
Stephanie Haack
Selina Göb
Anna Uri
Fred Lühder
Bernard Vanhove
Bernard Vanhove
Bernard Vanhove
Thomas Hünig
Niklas Beyersdorf

May 2018

Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimula...

In vitro MAP27 treatment promoted the production of IFN-γ in splenocytes from MAP27-immunized mice.

Xiang-Yu Wang (790019)
Zhao-Xia Huang (790020)
Yi-Guo Chen (593833)
Xiao Lu (355468)
Ping Zhu (11521)
Kun Wen (790021)
Ning Fu (68329)
Bei-Yi Liu (790022)

August 2015

Five days after the last boost immunization, splenocytes isolated from the mice (n = 5 mice per g...

CD28 costimulation of T helper 1 cells enhances cytokine release in vivo

Langenhorst, Daniela
Haack, Stephanie
Göb, Selina
Uri, Anna
Lühder, Fred
Vanhove, Bernhard
Hünig, Thomas
Beyersdorf, Niklas

January 2018

Compared to naive T cells, differentiated T cells are thought to be less dependent on CD28 costimula...

Ein neues Mausmodell zur Untersuchung der Zytokinfreisetzung nach Behandlung mit einem superagonistischen anti-CD28 Antikörper

Haack, Stephanie

January 2021

The adaptive immune system is known to provide highly specific and effective immunity against a broa...

IFN-γ signaling regulates the expansion of memory CD8+ T cells.

Yoshiko Iwai (49013)
Hiroaki Hemmi (49014)
Olga Mizenina (49015)
Shoko Kuroda (49016)
Koji Suda (49017)
Ralph M. Steinman (49018)

February 2013

(A, B) IL-18 production from DCs. (A) DCs isolated from spleen of IFN-γR1−/− and wild ...

CD43 is a murine T cell costimulatory receptor that functions independently of CD28.

Sperling, AI
Green, JM
Mosley, RL
Smith, PL
DiPaolo, RJ
Klein, JR
Bluestone, JA
Thompson, CB

July 1995

Costimulation mediated by the CD28 receptor has been shown to play an important role in the developm...

Rapid regulatory T-cell response prevents cytokine storm in CD28 superagonist treated mice.

Tea Gogishvili
Daniela Langenhorst
Fred Lühder
Fernando Elias
Karin Elflein
Kevin M Dennehy
Ralf Gold
Thomas Hünig

Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regul...

Rapid Regulatory T-Cell Response Prevents Cytokine Storm in CD28 Superagonist Treated Mice

Tea Gogishvili
Daniela Langenhorst
O Elias
Karin Elflein
Kevin M
Ralf Gold

January 2009

Superagonistic CD28-specific monoclonal antibodies (CD28SA) are highly effective activators of regul...

CD28 signaling increases CD226 expression and IL-3 secretion in CD4 T cells.

Manish J. Butte (154492)
Sun Jung Lee (154496)
Jonathan Jesneck (154500)
Mary E. Keir (154503)
W. Nicholas Haining (154505)
Arlene H. Sharpe (154508)

June 2012

Sorted naïve CD4+CD25- T cells from C57BL/6 wild type mice were stimulated with bead-bound anti-C...

Mouse CD8 alpha(+) DCs and human BDCA3(+) DCs are major producers of IFN-lambda in response to poly IC

Lauterbach, H
Bathke, B
Gilles, S
Traidl-Hoffmann, C
Luber, CA
Fejer, G
Freudenberg, MA
Davey, GM
Vremec, D
Kallies, A
Wu, L
Shortman, K
Chaplin, P
Suter, M
O'Keeffe, M
Hochrein, H

November 2010

Polyinosinic:polycytidylic acid (poly IC), a double-stranded RNA, is an effective adjuvant in vivo. ...

Helper effector function of human T cells stimulated by anti-CD3 mAb can be enhanced by co-stimulatory signals and is partially dependent on CD40-CD40 ligand interaction

Kwekkeboom, Jaap
De Rijk, Diana
De Groot, Cornelis
De Boer, Mark
Kasran, Ahmad
Barcy, Serge

March 1994

In this study we have investigated whether anti-CD3-induced human T cell help for immunoglobulin pro...

CD28 Deficiency Enhances Type I IFN Production by Murine Plasmacytoid Dendritic Cells.

Macal, M.
Tam, M.A.
Hesser, C.
Di Domizio, J.
Leger, P.
Gilliet, M.
Zuniga, E.I.

January 2016

Type I IFNs (IFN-I) are key innate mediators that create a profound antiviral state and orchestrate ...

Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

Abstract

Extracted data

Superagonistic CD28 stimulation induces IFN‐γ release from mouse T helper 1 cells in vitro and in vivo

Abstract

Extracted data

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