Background: Cerebral small vessel disease (SVD) is associated with increased cerebrovascular pulsatility, endothelial dysfunction, and impaired vascular reactivity. Vasodilating phosphodiesterase inhibitors may improve cardiovascular pulsatility and reactivity, and potentially reduce progression of SVD. Hypothesis: Sildenafil, a PDE5 inhibitor, will reduce cerebrovascular pulsatility and increase cerebrovascular reactivity compared to placebo, and is non-inferior to cilostazol, a PDE3 inhibitor. Methods: OxHARP is a randomised, double-blind, crossover trial of sildenafil 50 mg thrice daily, cilostazol 100 mg twice daily and placebo in 75 patients with mild to moderate small vessel disease and a previous lacunar or cryptogenic stro...
Objectives: Vasodilating antihypertensives prevent stroke and potentially cerebral small vessel dise...
Objectives: Vasodilating antihypertensives prevent stroke and potentially cerebral small vessel dise...
Small vessel disease encompasses lacunar stroke, white matter hyperintensities, lacunes and microble...
BACKGROUND: Cerebral small vessel disease (SVD) is associated with increased cerebrovascular pulsati...
Background Cerebral small vessel disease (SVD) is associated with increased cerebrovascular pulsa...
Background Cerebral small vessel disease (SVD) is associated with increased cerebrovascular pulsatil...
Background: Cerebral small vessel disease is a common cause of vascular cognitive impairment in ol...
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (S...
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (S...
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (S...
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (S...
Introduction: There are few randomized clinical trials in vascular cognitive impairment (VCI). This ...
Background Cerebral small vessel disease is a common cause of vascular cognitive impairment in ol...
RationaleThe pathophysiology of most lacunar stroke, a form of small vessel disease, is thought to d...
Background: Cerebral small vessel disease is a common cause of vascular cognitive impairment in olde...
Objectives: Vasodilating antihypertensives prevent stroke and potentially cerebral small vessel dise...
Objectives: Vasodilating antihypertensives prevent stroke and potentially cerebral small vessel dise...
Small vessel disease encompasses lacunar stroke, white matter hyperintensities, lacunes and microble...
BACKGROUND: Cerebral small vessel disease (SVD) is associated with increased cerebrovascular pulsati...
Background Cerebral small vessel disease (SVD) is associated with increased cerebrovascular pulsa...
Background Cerebral small vessel disease (SVD) is associated with increased cerebrovascular pulsatil...
Background: Cerebral small vessel disease is a common cause of vascular cognitive impairment in ol...
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (S...
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (S...
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (S...
Background: Hypertension is the leading modifiable risk factor for cerebral small vessel diseases (S...
Introduction: There are few randomized clinical trials in vascular cognitive impairment (VCI). This ...
Background Cerebral small vessel disease is a common cause of vascular cognitive impairment in ol...
RationaleThe pathophysiology of most lacunar stroke, a form of small vessel disease, is thought to d...
Background: Cerebral small vessel disease is a common cause of vascular cognitive impairment in olde...
Objectives: Vasodilating antihypertensives prevent stroke and potentially cerebral small vessel dise...
Objectives: Vasodilating antihypertensives prevent stroke and potentially cerebral small vessel dise...
Small vessel disease encompasses lacunar stroke, white matter hyperintensities, lacunes and microble...