Implications of Coexisting Aortic Regurgitation in Patients With Aortic Stenosis

Jinghao Nicholas Ngiam, MBBS
Nicholas W.S. Chew, MBBS
Thanawin Pramotedham, MBBS
Benjamin Yong-Qiang Tan, MBBS
Ching-Hui Sia, MBBS
Poay Huan Loh, MBBS
Wen Ruan, MD
Edgar Tay, MBBS
William K.F. Kong, MBBS
Tiong-Cheng Yeo, MBBS
Kian-Keong Poh, MBBChir

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Publication date

June 2021

DOI

10.1016/j.jacasi.2021.05.004

Publisher

Elsevier BV

Journal

issn:2772-3747

Abstract

Background: Aortic regurgitation (AR) is a common comorbidity in patients with aortic stenosis (AS), but coexisting AR has often been excluded from major clinical studies on AS. The impact of coexisting AR on the natural history of AS has not been well-described. Objectives: The authors compared clinical outcomes in medically managed patients with moderate-to-severe AS with or without coexisting AR. Methods: Consecutive patients (N = 1,188) with index echocardiographic diagnosis of moderate-to-severe AS (aortic valve area <1.5 cm2) were studied. All patients were medically managed and were divided into those with coexisting AR (at least moderate severity) and those without. Adverse composite clinical outcomes were defined as mortality or ad...