Sepsis is a potentially lethal condition characterized by systemic inflammation and multiple organ failure, and sepsis-associated encephalopathy (SAE) is an independent risk factor for mortality in patients with sepsis. We previously reported that orexin improved survival in an animal model of sepsis by acting in the brain. Peripherally administered orexin entered the brain under the conditions of systemic inflammation because of BBB dysfunction and produced survival-related effects. As a therapeutic concept, we hypothesized that orexin treatment enhances recovery from sepsis by restoring reduced orexin levels in cerebrospinal fluid (CSF). Here, we report that CSF orexin levels were reduced in a 63-year-old woman with sepsis. The patient pr...
Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of dea...
Septic associated encephalopathy (SAE) is simply define as an encephalopathy incidence that occurs i...
Contains fulltext : 52472.pdf (publisher's version ) (Closed access)BACKGROUND: Id...
International studies demonstrate an annual increase in the frequency and impact of sepsis in intens...
Sepsis associated encephalopathy (SAE) is a common but poorly understood neurological complication o...
OBJECTIVE: We investigated whether serum levels of neuron-specific enolase (NSE) and S-100β protein ...
# The Author(s) 2013. This article is published with open access at Springerlink.com Abstract Every ...
The pathogenesis of sepsis associated encephalopathy (SAE) is not yet clear: the blood–brain barrier...
he pathogenesis of sepsis associated encephalopathy (SAE) is not yet clear: the blood-brain barrier ...
Abstract Background Brain homeostasis deteriorates in sepsis, giving rise to a mostly reversible sep...
Every year, more cases of sepsis appear in intensive care units. The most frequent complication of s...
Objective: We investigated whether serum levels of neuron-specific enolase (NSE) and S-100 beta prot...
The pathophysiology of sepsis-associated encephalopathy (SAE) is complex and remains incompletely el...
Sepsis is a major cause of mortality and morbidity in intensive care units. Organ dysfunction is tri...
Cardiac arrest (CA) affects >550,000 people annually in the United States whereas 80-90% of survi...
Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of dea...
Septic associated encephalopathy (SAE) is simply define as an encephalopathy incidence that occurs i...
Contains fulltext : 52472.pdf (publisher's version ) (Closed access)BACKGROUND: Id...
International studies demonstrate an annual increase in the frequency and impact of sepsis in intens...
Sepsis associated encephalopathy (SAE) is a common but poorly understood neurological complication o...
OBJECTIVE: We investigated whether serum levels of neuron-specific enolase (NSE) and S-100β protein ...
# The Author(s) 2013. This article is published with open access at Springerlink.com Abstract Every ...
The pathogenesis of sepsis associated encephalopathy (SAE) is not yet clear: the blood–brain barrier...
he pathogenesis of sepsis associated encephalopathy (SAE) is not yet clear: the blood-brain barrier ...
Abstract Background Brain homeostasis deteriorates in sepsis, giving rise to a mostly reversible sep...
Every year, more cases of sepsis appear in intensive care units. The most frequent complication of s...
Objective: We investigated whether serum levels of neuron-specific enolase (NSE) and S-100 beta prot...
The pathophysiology of sepsis-associated encephalopathy (SAE) is complex and remains incompletely el...
Sepsis is a major cause of mortality and morbidity in intensive care units. Organ dysfunction is tri...
Cardiac arrest (CA) affects >550,000 people annually in the United States whereas 80-90% of survi...
Sepsis is a systemic inflammatory response to infection, accounting for the most common cause of dea...
Septic associated encephalopathy (SAE) is simply define as an encephalopathy incidence that occurs i...
Contains fulltext : 52472.pdf (publisher's version ) (Closed access)BACKGROUND: Id...