Carteritins A and B, cyclic heptapeptides from the marine sponge Stylissa carteri
- Afifi Ahmed H.
- El-Desoky Ahmed H.
- 加藤 光
- Mangindaan Remy E.P.
- de Voogd Nicole J.
- Ammar Nagwa M.
- Hifnawy Mohammed S.
- 塚本 佐知子
- Ahmed H. Afifi
- Ahmed H. El-Desoky
- Hikaru Kato
- Remy E.P. Mangindaan
- Nicole J. de Voogd
- Nagwa M. Ammar
- Mohammed S. Hifnawy
- Sachiko Tsukamoto
Publication date
March 2016
DOI Publisher
Elsevier BV Journal
Tetrahedron LettersAbstract
Two new cyclic heptapeptides, carteritins A and B (1 and 2), were isolated from the marine sponge Stylissa carteri along with three known cyclic heptapeptides, phakellistatin 13 (3) and hymenamides C and D (4 and 5). Their structures were elucidated based on data obtained using 2D NMR, HRESIMS, and ESIMS/MS, in addition to Marfey’s analysis. Carteritin A (1) showed cytotoxicities against HeLa, HCT116, and RAW264 cells with IC50 values of 0.70–1.5 μM
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